X. EFFECTS OF DEFICIENCY 



280 



tlic infant was hnspilalizcil. . . . On llic -"^iU tiay <>!' lio.si)ilali/.al ittn, the infant went 

 into status ('i)ilt>ptious. Tlic oycs icniaintMl IixcmI anil staiinj!;, pupils (-(tnt ractcd with 

 no reaction to lifjht. The ixxly was held rij^idly with the head thrown hack. General- 

 ized convulsive movements recurred rei)eatedly with occasional outi)ursts of an 

 abnormally hi^h-i)itched monotonous cry. There was some evidence of cyanosis ahout 



^/ \A.. f\j^A^ 



■ I sec. .Zmiti 



Fk;. 2. Kleetroencephalojiram during convulsion in an infant on a vitamin Be-de- 

 ficient milk formula. 



_!_J§Cj7wn. 



¥n;. 3. Electroencephalogram taken from the same infant (Fig. 2) 3 miimtes after 

 intramuscular injection of 100 mg. of i)\ri(io\iiie-ITC'l. 



the lips. There was no response to painful stimuli. Pulse was rapid and regular at ISO. 

 Respirations were gasping at 40. The patient was placed in oxygen with some im- 

 l)rovement of color hut no effect on the seizures. He was removed to the EEG labora- 

 tory and connected by means of needle electrodes to the EEG apparatus. Continuous 

 recording was undertaken with great technical difliiculty due to the child's muscular 

 activity. However, successful tracing was olitained with evidence of markedly in- 

 creased voltage of 200 fiv and slowing to 2-3 waves per sec. These appeared in bursts 

 with recurrently accompanying spikes and lasted for 4-6 sec. . . . This pattern of 



