300 RIBOFLAVIN 



Page 



2. Colorimetric and Polarigraphic Methods 368 



3. Enzymatic Methods 369 



B. Biological Methods 369 



C. Microbiological Methods 372 



VIII. Standardization 373 



IX. Occurrence in Food 374 



X. Effects of Deficiency 377 



A. In Microorganisms 377 



B. In Plants 379 



C. In Insects 379 



D. In Animals 380 



1. Rats 380 



2. Dogs and Foxes 3S1 



3. Pigs 3S,5 



4. Young Ruminants 385 



5. Other Mammals 386 



6. Birds 386 



E. In Man 387 



1. Oral and Facial Lesions of Aribofiavinosis 388 



2. Lesions of Scrotum and Vulva 389 



3. Ocular Manifestations 390 



XL Pharmacolog.y 391 



XII. Requirements and Factors Influencing Them 394 



A. Of Animals 394 



1. Effect of Dietary Constituents 396 



2. Effect of Environment 397 



3. Reproduction 397 



4. Inherent Individual Variations 397 



5. Other Factors 398 



B. Of Man 398 



I. Nomenclature 



ROBERT S. HARRIS 



Accepted names: Riboflavin (U.S. Pharmacopeia) 



Riboflavine (British Pharmacopoeia) 



Obsolete names: Vitamin B2 Ovoflavin 

 Vitamin G Lyochrome 



Lactoflavin Uroflavin 



Hepatoflavin 



Empirical formula: C17H20N4O6 



Chemical name: 6 ,7-Dimethyl-9-(D-l'-ribityl)isoalloxazine 



