386 RIBOFLAVIN 



Riboflavin deficiency has also been observed in young lambs reared on 

 artificial diets.^^ 



5. Other Mammals 



Mice show effects*^' ^* quite similar to those described for rats. A histo- 

 logical basis for the inhibition of lengthwise growth in ribofiavin-deficient 

 animals has been suggested in studies of endochondral ossification in mice.^^ 



Rhesus monkeys^^ develop a freckled type of dermatitis on face, hands, 

 legs, and groin, and a hypochromic, normocytic anemia, both of which are 

 improved by riboflavin administration. Fatty livers which cannot be re- 

 lated to inanition have also been demonstrated in these monkeys. 



The similarity between periodic ophthalmia in horses during the course 

 of which corneal vascularization and cataracts frequently occur, and ribo- 

 flavin deficiency in experimental animals, has suggested a possible common 

 etiology.^^ It has been reported^* that riboflavin is effective in preventing 

 the appearance of equine periodic ophthalmia but that it does not influence 

 the course of the disease in established cases. Studies of horses on diets 

 low in riboflavins^ have shown a correlation between their urinary excretion 

 and their dietary intake. 



6. Birds 



The economic importance of poultry raising has stimulated much excel- 

 lent research on the vitamin requirements of birds. The needs of chicks 

 and fowls for growth and egg laying have been assayed by many investi- 

 gators. ^"'^^ During these studies peculiar pathological syndromes have been 



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