404 THIAMINE 



Page 



X. Effects of Deficiency 460 



A. In Microorganisms 460 



B. In Animals 460 



C. In Man 464 



XI. Pharmacology 466 



XII. Requirements and Factors Influencing Them 472 



A. Of Animals 472 



B. Of Man 478 



I. Nomenclature 



ROBERT S. HARRIS 



Accepted name: Thiamine (U. S. A.) 



Aneurin (Brit. Pharm.) 

 Obsolete names: Vitamin Bi 



Oryzamin 



Torulin 



Polyneuramin 



Vitamin F 



Antineuritic vitamin 



Antiberiberi vitamin 



Empirical formula : C12H17N4OSCI • HCl 



Chemical name : 3-(4-Amino-2-methy]pyrimidyl-5-methyl)-4-methyl-5-|3- 



hydroethylthiazolium chloride hydrochloride 



Structure : 



HCl CH3 



I I 



N=C— NH2 Ci=^C— CH.— CHoOH 



13 41 / 



|2 5| / 



H3C— C C— CHo— N3 



111 ell V 1 



N— CH CH— S 



II. Chemistry 



B. C. P. JANSEN 

 A. ISOLATION 



After Eijkman's discovery that polished rice was the cause of polyneu- 

 ritis in birds and of beriberi in men, Grijns,^ his successor in Batavia, was 



1 G. Grijns, Geneesk. Tijdschr. Ned. Indie 41, 3 (1901). (Dutch; afterwards trans- 



