480 THIAMINE 



Holt et al.^'^ found the thiamine requirement of seven infants to vary 

 between 0.14 mg. and 0.20 mg. per day on the basis of a urinary excretion 

 test. With an average tliiamine content of cow's milk of 0.35 to 0.4 mg. 

 per liter, an infant weighing 7 kg. is calculated to receive at least 0.3 mg. 

 of thiamine a day, but this makes no allowance for destruction by heat in 

 pasteurization or sterilization. The margin of safety is, therefore, regarded 

 as small by Holt and coworkers in the case of either sterilized milk or breast 

 milk, since the latter contains roughly only half as much thiamine as cow's 

 milk. 



The meager data available on the thiamine requirement in pregnancy 

 and lactation^^'^^ indicate that in relation to calories the requirement may 

 be considered to be in the same proportion as for infants and adult men. 



«o L. E. Holt, Jr., R. L. Nemir, S. E. Snyderman, A. A. Albanese, K. C. Ketron, 



L. P. Guy, and R. Carretero, J. Nutrition 37, 53 (1949). 

 61 H. Oldham, B. B. Sheft, and T. Porter, Federation Proc. 6, 416 (1947). 

 «2 M. Kaucher, E.'Z. Moyer, A. J. Richards, H. H. Williams, A. L. Wertz, and I. G 



Macy, Am. J. Diseases Children 70, 142 (1945). 

 63 C. Roderick, H. H. Williams, and I. G. Macy, /. Nutrition 32, 249 (1946). 



