482 



THE TOCOPHEROLS 



Page 

 yill. Pharmacology 562 



A. Hypervitaminosis E 563 



B. Mode of Administration 563 



C. Metabolic Stress in Animals 563 



D. Therapeutic Use 564 



1. Heart Disease 565 



2. Peripheral Vascular Disease 566 



3. Menopausal Syndrome 567 



4. Primary Fibrositis and Related Disorders 568 



5. Diabetes Mellitus 569 



6. General Comments 570 



IX. Requirements and Factors Influencing Them 570 



A. Of Animals 570 



B. Of Man 572 



I. Nomenclature 



ROBERT S. HARRIS 



Accepted names: Vitamin E 



Tocopherol 



Obsolete names: Factor "X" 



Antisterility vitamin 

 Empirical formulas: a-Tocopherol : C29H50O2 

 iS-Tocopherol : C28H480-2 

 7-Tocopherol : C28H48O2 

 5-Tocopherol : C27H46O2 

 Chemical names : a-Tocopherol : 2 , 5 , 7 , 8-tetramethyl-2-(4' , 8' , 12'-trimeth- 

 yldecyl)-6-chromanol, or 5 , 7 , 8-trimethyltocol 

 /3-Tocopherol: 2 ,5 ,8-trimethyl-2-(4' ,8' , 12'-trimethylde- 



cyl)-6-chromanol, or 5 , 8-dimethyltocol 

 7-Tocopherol: 2 ,7 ,8-trimethyl-2-(4' ,8' , 12'-trimethylde- 



cyl)-6-chromanol or 7 , 8-dimethyltocol 

 5-Tocopherol : 2 , 8-dimethyl-2-(4' , 8' , 12'-trimethylde- 

 cyl)-6-chromanol, or 8-methyltocol 



Structures : 



CH3 

 H3C I CH 



■ 1 2' 



HO 



1 



CH 



CH3 CH3 CHs 



I I I 



(CH2)3CH(CH2)3CH(CH2)3CHCH3 



a-Tocopherol 



