552 



THE TOCOPHEROLS 



Plasma tocopherol levels in iiewl)orn infants are approximately one- 

 third to one-fourth those found in healthy adults. Average values of 0.23 

 mg. % (S.D. ± 0.13),i«7 0.37 mg. % (S.D. ± 0.15),'^^ and 0.43 mg. % 

 (S.D. ± 0.12)1^* have been reported. For young and adolescent children, 

 values of about 1 mg. % are considered normal. ^^^ Plasma tocopherol levels 

 for healthy adults usually fall within the range of 1.0 to 1.2 mg. % (see 

 Table IV). During pregnancy there is a rather pronounced increment in 

 plasma tocopherols/^'*' ^^^' i^^-i^i which declines only gradually during lac- 



" Method of Quaife and coworkers.i'^- '" 



tation.^^*' "^ A tendency for values to increase with age has been 

 reported."" • i" 



(2) Effect of Disease. Compared to normal healthy adults, clinic pa- 

 tients^^^ and convalescent hospital patients randomly selected^^^- ^^^' -^'^ 



196 A. S. Minot, J. Lab. Clin. Med. 29, 772 (1944). 

 i"M. Chieffi and J. E. Kirk, J. Gerontol. 6, 17 (1951). 



198 P. L. Harris, K. C. D. Hickman, J. L. Jensen, and T. D. Spies, Am. J. Public 

 Health 3G, 155 (1946). 



199 J. M. Lemley, R. G. Gale, R. H. Furman, IM. E. Cherrington, W. J. Darby, and 

 G. R. Meneely, Am. Heart J. 37, 1029 (1949). 



200 G. Klatskin and W. A. Krehl, J. Clin. Invest. 39, 1528 (1950). 



A 



