VII. EFFECTS OF DEFICIENCY 



553 



have somewhat lower levels of plasma tocopherol (Table IV). Patients with 

 liver disease also tend to show low values,-""-"* Init they are not signifi- 

 cantly dirterent from those of convalescent patients with no evidence of 

 liver disease;*"' -"" the same is true of cardiac patients.*'^ Lower-than-usual 

 values are also commonly observed in diseases where intestinal absorption 

 is defective, as in sprue,-"-- -"' celiac disease, fibrocystic disease of the pan- 

 creas, biliary obstruction, and diarrhea associated with achlorhydria.""' *^^ 

 This is in accord with experimental evidence that surgical production of a 



DISEASES ASSOCIATED WITH 

 HYPERCHOLESTEROLEMIA 



PREGNANCY 



MISCELLANEOUS METABOLIC 

 AND INFECTIOUS DISEASES 



ABSORPTIVE DEFECTS 



Mg. /lOOcc. 



Fig. 8. Range of plasma tocopherols in man in relation to good health, pregnane}', 

 and certain broadly classified diseases (from Darbj' el ai."°). 



biliary fistula leads to a state of vitamin E deficiency in the rat and dog. 

 On the other hand, higher-than-usual values are freciuently observed in 

 diseases associated with hypercholesteremia and in cardiovascular disease 

 and pregnancy, both of which are often associated with increased blood 

 lipids.*"" (Fig. (S). These deviations from normal might l)e explained, accord- 



2"' II. Popper, A. Dul)in, F. .Stcigmanii, ami F. P. lles.scr, ./. Lab. Clin. .Med. 34, 618 

 (1949). 



202 VV. J. Darby, M. E. Cherrington, and J. M. Uuffin, Proc. Soc. Expll. Biol. Med. 63, 

 310 (1946). 



203 W. J. Darby, E. Jones, IT. F. Warden, and M. M. Ka,ser, ./. .Xutrilinn 34, 64.5 

 (1947). 



