644 



SUBJECT INDEX 



Aldehyde oxidase, 



mechanism of action, 351 



preparation, 350 



properties, 350-351 

 Alloxan, 44, 444, 564 



effect on growth, 323 



in riboflavin synthesis, 314-315 



preparation of, 320 



tocopherol and, 537, 546 

 AUoxantin, tocopherol and, 546 

 A-Methopterin, see also 4-Amino-Ni''- 

 methylpteroylglutamic acid 



effect on purine synthesis, 133 

 p-Aminoacetoi^henone, in thiamine esti- 

 mation, 449-450 

 Amino acid decarboxylases, coenzyme 



of, 234-236 

 D-Amino acid oxidase, 393 



coenzyme of, 343 



in flavin nucleotide estimation, 369 



in vitamin Be deficiency, 269 



mechanism of action, 352 



preparation, 352 



riboflavin analogs and, 328-329 



specificity of, 351-352 

 L-Amino acid oxidase, 



coenzyme of, 334 



preparation, 353 



properties, 353-354 



specificity and mechanism of action, 

 353-354 

 Amino acids, 33 



in old yellow enzyme, 340-341 



pteroyl derivatives of, 154-155 



synthesis, pteroylglutamic acid and, 

 136-137 

 p-Aminobenzoic acid, 



absorption of, 52 



acetylation in disease, 48 



as sun-screening agent, 6, 60 



biochemical systems of, 13-16 



biogenesis of, 16-19 



by microorganisms, 34r-36 



bound forms of, 27-28 



chemistry, 2-12 



color reactions of, 11-12 



degradation of, 6 



derivatives of, 10 



detoxification of , 44, 52-53 



diazotization of, 7, 11, 19-21 



differentiation from isomers, 11-12 



effect of ionization on requirement, 32 

 effects of deficiency, 



in bacteria, 32-36 



in chicks, 42 



in fish, 43 



in hamsters, 42 



in mice, 41-42_, 



in rats, 37-41 ' 



in swine, 42-43 

 effect on, 



aminoimidazole utilization, 132 



pteroylglutamic acid synthesis, 133- 

 134 



trypanosomes, 65 



tumors, 41-42 

 estimation of, 



chemical methods, 19-21 



microbiological methods, 21-27 

 excretion, 52-53 



in human, 46-49 



in lower animals, 43-46 

 halogenation of, &-7 

 in amino acid synthesis, 136 

 industrial preparation, 12-13 

 inositol and, 38 

 in pteroylglutamic acid estimation, 



161-162 

 in purine synthesis, 129 

 in rhizopterin, 109 

 in sulfanilamide requirement, 76-77 

 in sulfonamide resistance, 66-68 

 ionization of, 4 

 nomenclature, 2 

 occurrence in foods, 27-31 

 oxidation of, 25-26 

 paper chromatography of, 21 

 pentosides and hexosides of, 10 

 peptides of, 9, 13-14 

 pharmacology of, 52-62 

 properties of, 3-6 

 salt and esters of, 7-10, 65 

 sulfonamide reversal and, 66-79, 127- 



128, 172 

 therapeutic activity of, 79-85 

 therapeutic uses of, 59-62 

 toxicity, 53-55 



in humans, 51-52 



in lower animals, 49-51 

 tyrosinase and, 15 

 ultraviolet absorption of, 4-6 



