SUBJECT INDEX 



645 



uriuiuy metabolites of, 46, 47-48 

 vitamin B12 iuui, 18-19 

 p-Aminohetizojlglutamic aciil, 15, 16, 

 33, 34, 113 

 in folif acid, 98-99 



in folic acid synthesis, 104, 107-lOS, 122 

 in sulfonamide reversal, 73-74 

 p-Aminobenzoyl-i>-glutamic acid, 155 

 p-Aminobenzoylglycine, effect on 



growth, 25 

 4-Amino-9,10-dimethylpteroylglutamic 



acid, as inhibitor, 157, 160 

 2-Amino-4,5-dimethyl-l-ribitylamino- 



benzene, effect on growth, 323 

 Aminoethanol, in choline sj'nthesis, 141 

 P'Aminohippuric acid, 21, 46, 53 



biosj'nthesis of, 14 

 2-Amino-4-h}'droxy-5-form3l-10-meth3d- 

 5, 6, 7, 8-tetrahj'dropteroylglu- 

 tamic acid, reaction with nitrous 

 acid, 117 

 2-Amino-4-hydroxy-6-methylpteridines, 

 in pteroylglutamic acid synthesis, 

 105, 107-108, 122-123 

 2-Amino-4-hydroxypteridine-6-alde- 



hyde, 349 

 2-Amino-4-hydroxypteridine-6-carbox- 

 }iic acid, 

 formation from pteroylglutamic acid, 



96 

 in pteroylglutamic acid estimation, 162 

 2-Amino-4-hj'droxypteridines, as inhibi- 

 tors, 152-153 

 2-Amino-4-hydroxj^-6-pteridyl-methyl- 

 (4'-methyl-5'-hydroxyethylthiaz- 

 olium)bromide, 15 

 5(4)-Amino-4(5)-imidazolecarboxamide, 

 20 

 accumulation of, 69-70 

 in purine synthesis, 128-132 

 synthesis, formate and, 139 

 Aminomethj'lene malononitrile, in thi- 

 amine synthesis, 417 

 4-Amino-9-methylpteroylglutamic acid, 



as inhibitor, 160 

 4-Amino-Ni°-methylpteroylglutamic 

 acid, see also A-mcthopterin 

 as inhibitor, 160 

 a- Amino-/3- (4-methylthiazole-5) -propi- 

 onic acid, in thiamine biogenesis, 

 447 



/j-Aminophenylactic acid, 

 as growth factor, 32 

 ofTect on thyroid gland, 41 

 Aminoplorin, see (tlso 4 Ainiiiopteroyl- 

 giutamic acid, 

 citrovorum factor and, IIU 

 effect on purine synthesis, 130, 133 

 methionine synthesis and, 137 

 resistance to, 159 

 4-Aminopteroyl alanine, 157 

 4-Aminoptero3iaspartic acid, as in- 

 hibitor, 160 

 4-Aminoptero3iglutamic acid, see alsa 

 Aminopterin 

 as inhibitor, 160 

 citrovorum factor and, 197-198 

 derivatives, as inhibitovs, 157-159 

 effect in humans, 213-215 

 estradiol and, 196 

 reversal of, 157-158 

 2-Aminopurine, as inhibitor, 151 

 p-Aminosalic3'lic acid, 21 



p-aminobenzoic acid and, 78-79 

 Aminotocojiherol, activity of, 491 

 5-Aminouracil, as inhibitor, 150 

 Ammonium acetate, pjridoxine and, 291 

 Amj'lcaine, 8 

 Anaphjdactic shock, thiamine and, 470- 



471 

 Anemia, 

 achrestic, 205 



p-aminobenzoic acid and, 55 

 in vitamin Be-deficiency, 281 

 megaloblastic, 

 ascorbic acid and, 193-195 

 idiopathic, 205 

 of infancy, 207-208 

 of pregnancy, 205-207 

 pteroylglutamic acid and, 193-195 

 vitamin B,2 and, 193-195, 209-213 

 nutritional, macrocytic, 203-205 

 Anesthesine, 8 

 Anesthetics, derived from p-aminol)en- 



zoic acid, 7-10 

 Aneurin, sec Thiamine 

 Anhydrolcucovoriiis, formation of, 119- 



120 

 X-(2-Anilinoethyl)-formanilide, resem- 

 i)lance to Icucovorin, 118-119 



