654 



SUBJECT INDEX 



Leucine, 9 



peptides, requirement for, 586 

 Leucoriboflavin, 312 

 Leucovorin, see also Citrovorum factor 

 isomers of, 120-121 

 reaction with nitrous acid, 118 

 Leukemia, 

 pyrimidine analogs and, 151 

 vitamin Be and, 284-285 

 Lewisite, pyruvic oxidase and, 581-582 

 Light, effect on riboflavin in foods, 376- 



377 . 

 Linoleic acid, 

 tocopherol and, 512 

 vitamin Be and, 266, 269, 295 

 Lipoic acid, 

 discovery of, 576 

 disulfide, bond energy of, 583 

 forms of, 577 



free radical, in photosynthesis, 582-583 

 function of, 579-580, 581 

 isolation of, 577 

 Lewisite and, 582 

 potency of, 577 



regeneration of oxidized form, 580-581 

 structure of, 577-578 

 synthesis of, 578 

 Lipoic acid sulfoxide, 578 

 Lipothiamide, properties of, 578-579 

 Lipothiamide pyrophosphate, properties 



of, 579 

 Liver, 

 in riboflavin deficiency, 384 

 in tocopherol deficiency, 539-540 

 Liver disease, 

 ceroid and, 556 

 tocopherol and, 553, 554 

 Lumichrome, formation from riboflavin, 



309-310 

 Lumiflavin, 303, 362 

 effects on growth, 330 

 formation from riboflavin, 309 

 in riboflavin assay, 366-367 

 Lupus erythematosus, tocopherol and, 



554, 569 

 Lycomarasmin, strepogenin and, 585-586 

 Lyochrome, see Riboflavin 

 Lysine, 



in sulfonamide reversal, 69 

 requirement for, 279 



Lyxoflavin, 



effects on growth, 327, 358 



isolation of, 588 



synthesis of, 320 

 Lyxose, isolation of, 588 



M 



Magnesium, 



carboxylase and, 442 

 dietary, in stiffness syndrome, 592 

 Malic acid, in detoxification, 44 

 Malonic acid, 436 



as enzyme inhibitor, 14 

 in thiamine synthesis, 413, 414 

 Malononitrile, in tliiamine synthesis, 



413, 414^415 

 Mapharsen, 58 

 Mapharside, 63, 65 

 Meat, thiamine in, 457-458 

 Melanine, 48 



Menopause, tocopherol and, 567 

 Mepacrine, see Atabrin 

 Metals, in carboxylase activation, 442 

 Mesoxalic acid, 443 



Methanol, utilization for choline syn- 

 thesis, 142 

 Methionine, 135-136, 198 



p-aminobenzoic acid and, 34 

 Methionine, 



effect in pteroylglutamic acid defi- 

 ciency, 139 

 in antioxygenic action, 503-504 

 in sulfanilamide requirement, 76-77 

 in sulfonamide reversal, 69, 127-128 

 in thiamine biogenesis, 447 

 in vitamin Be deficiency, 270 

 synthesis, 



pteroylglutamic acid and, 137, 174 

 vitamins and, 140-142 

 tocopherol and, 539-540 

 vitamin Be and, 294-295 

 2-Methyl-4-aminopyrimidyl-5-mcthyl- 



aminodihydrochloride, in carbox- 

 ylase activation, 428-429 

 (Methylbis-/3-chloroethyl)amine, effect 

 on p-aminohippuric acid synthesis, 



14 

 2-Methyl-5-bromomethyl-6-aminopyrim- 



idine, linkage with thiazole, 421- j 



423 



