658 



SUBJECT INDEX 



in methionine synthesis, 137, 140-142 



in purine synthesis, 138-139 



in radiation sickness, 291 



in serine synthesis, 136-138 



in sulfonamide reversal, 68-69, 70, 71 



isolation of, 91-93 



mechanism of action, 128^142 



nomenclature of, 89-91 



pharmacology of, 216-217 



polyglutamates, 28 

 isolation of, 93-94 



proof of structure, 96-97 



properties of, 99-104 



reaction with nitrous acid, 103, 118 



reduction potential of, 111 



relation to ascorbic acid, 191-195 



relation to other vitamins, 173-174 



release, xanthopterin and, 147-149 



requirements, of human, 217 



riboflavin and, 382-383 



specificity of, 109-121 



specificity of action, 142-161 



standardization of activity, 168 



synthesis of, 15, 104-108 



toxicity of, 216-217 



utilization in pernicious anemia, 212 

 Pteroylheptaglutamic acid, 178, 209, 210 



in pernicious anemia, 212-213 

 Pteroyltriglutamic acid, 33, 34, 160, 177, 

 178, 181, 209, 210 



effect on tumors, 161 

 Purines, 33, 135-136, 167 



pteroylglutamic acid and, 124-127 



in p-aminobenzoic acid estimation, 22, 

 25 



substituted, as pteroylglutamic acid 

 antagonists, 151-152 

 Putrescine, oxidation of, 356 

 Pyramine, estimation, 452 

 Pyridine nucleotide, in pyruvic acid oxi- 

 dation, 440 

 Pyridoxal, see also Vitamin Be 



activity, 

 for chick, 252 



for microorganisms, 254, 276-277 

 for rat, 251-252 



differentiation from pyridoxine, 248 



formation of, 231-232 



in tyrosine decarboxylation, 239 



toxocity of, 290 



I 



Pyridoxal phosphate, 442 



as coenzyme, 234, 278 



formation of, 240-241 



in growth of microorganisms, 277 



in transamination, 237-238 



mechanism of action, 241-242 



structure of, 240 

 Pyridoxamine, see also Vitamin Be 



activity, 

 for chick, 252 



for microorganisms, 254, 276-277 

 for rat, 251-252 



differentiation from pyridoxine, 248- 

 249 



formation of, 231-232 



toxicity of, 290 

 Pyridoxamine phosphate, 



as cotransaminase, 237 



in growth of microorganisms, 277 

 Pyridoxic acid, 281 



excretion of, 292 



pteroylglutamic acid and, 178 

 Pyridoxine, 34, 35, see also Vitamin Be 



biochemical systems, 234-239 



coenzyme form of, 234 



excretion of, 291-292 



industrial preparation, 233 



in growth of microorganisms, 276-277 



pharmacology of, 290-293 



proof of structure, 226-229 



purity standards, 233 



synthesis of, 229-231 



toxicity of, 292-293 

 Pyrimidines, 



pteroylglutamic acid, and, 124-127 



ring closure in thiamine synthesis, 415- 

 417 



substituted, 



as pteroylglutamic acid antagonists, 



150-151 

 riboflavin and, 330 

 Pyri thiamine, 442 



action of, 465 



as inhibitor, 447-448 

 Pyruvate oxidation factor, see Lipoic 



acid 

 Pyruvic acid, 44, 238 



carboxylation of, 433 



decarboxylation of, 443-445 ■ 



dismutation, 579 ' 



I 



