SUBJECT INDEX 



659 



formation from acetate, 436 



in thiamine deficiency, 462, 465 



oxidation, 

 coenzymes reciuired, 440 

 phosphorylation and, 434-436 



thiamine and, 426-427 



transamination of, 236 

 Pj-ruvic dehydrogenase, 427 



distinction from carboxylase, 432-433 

 Pyruvic oxidase, 435 



lipoic acid in, 581 



Quinic acid, in aromatic biosynthesis, 16 

 Quinine, ril)ofiavin and, 330, 393 

 Quinoxaline-2-carbox3^1yl-p-aminoben- 



zoylglutamic acid, activity of, 153 



Rabbit, tocopherol deficiency in, 518, 



525-526, 530 

 Racemases, coenzj-me of, 238 

 Radiation sickness, vitamin Be and, 285- 



286,291,293, 296 

 Rat, 

 p-aminobenzoic acid deficiency in, 37- 



41 

 assay, 

 for riboflavin, 369-370 

 for tocopherol, 509-511 

 pteroj'lglutamic acid deficiency in, 



171-175 

 pyridoxine requirement of, 294-295 

 riboflavin deficiency in, 380-383 

 tocopherol deficiency in, 517-518, 519- 

 520, 526-527, 530-533, 537, 538-539, 

 540, 541 

 vitamin Be deficiency' in, 265-270 

 Rat growth test, in pyridine estimation, 



251-252 

 Reductone, 

 in pteroylglutamic acid s^'nthesis, 122 

 in sulfonamide reversal, 74 

 Reproductive system, 

 female, in tocopherol deficiencj-, 519- 



521 

 male, in tocoj)herol deficicncj', 517-519 

 tocopherol and, 560-562 

 Reproduction, 

 in riboflavin deficiency, 383 



in vitamin Be deficiency, 265 

 pteroylglutamic acid and, 174-175, 



179-180 

 riboflavin requirement and, 397 

 Retrolental fibroplasia, tocopherol and, 



548-549 

 Rheumatic fever, p-aminobenzoic aciil 



and, 51-52, 55, 61-62, 81-83 

 Rhizopterin, 28, see also N^o-Formyl- 

 pteroic acid 

 chemistry of, 109 

 Rhodoflavin, 312 



formation of, 314 

 Ribamine, in riboflavin sj^nthesis, 316 

 Riboflavin, 160 



adsorption of, 304-305 

 analogs, 

 mode of action, 330-331 

 phenazine, 330, 393 

 antagonists of, 327-331 

 biochemical systems, 334-357 

 biogenesis of, 359-361 



by fungi, 360 

 blanks, in assay, 365-366 

 bound forms, 304 



hydrolysis of, 362-363 

 chemistry of, 301-332 

 constitution, 309-314 

 degradation products of, 309-311 

 derivatives, activity of, 306-307, 358, 



359 

 effects of deficiency, 

 in animals, 380-387 

 in human, 387-391 

 in insects, 379-380 

 in microorganisms, 377-379 

 in plants, 379 

 estimation, 



biological methods, 369-371 

 microbiological methods, 372-373 

 physical and chemical methods, 361- 

 369 

 excretion of, 392 

 extraction of, 304, 373 

 fluorescence of, 307 

 history of, 301-303 

 in detoxification, 45 

 industrial ])reparation, 332-333 

 in sulfonamide reversal, 77 

 in vitamin Be deficiencj', 270 



