662 



SUBJECT INDEX 



chemical, 448-450 



fermentative, 450-451 



microbiological, 451-453 



physical, 448 

 in carboxylase activation, 428-431 

 in detoxification, 45 

 industrial preparation, 



biosynthetic, 411 



from natural sources, 409-411 



patent situation, 424-425 



synthesis, 411-424 

 in peripheral nerves, 463-464 

 isolation of, 404-405, 410-411 

 nomenclature, 404 

 occurrence in food, 454-458 

 oxalacetate and, 434 

 pharmacology of, 466-471 

 properties of, 406 

 pyridoxine and, 279-280, 294 

 requirements, 



of animals, 472-478 



of human, 478-480 

 specificity of, 408-409 

 standardization of activity, 453-454 

 synthesis, 406-408 



by animal tissues, 409 

 toxicity of, 466, 468-470 

 Thiamine disulfide pyrophosphate, ac- 

 tivity of, 441 

 Thiamine monophosphate, 437, 442 

 in thiamine pyrophosphate synthesis, 

 439 

 Thiamine polyphosphate, 437-438 



activity of, 443 

 Thiamine pyrophosphate, 578, 579 

 as coenzyme, 427 



dissociation from apoenzymes, 427-431 

 essential metals, 442 

 estimation, 450-451 

 in determining thiamine requirement, 



477-478 

 in pyruvate oxidation, 435 

 occurrence of, 454-455 

 specificity of action, 442-445 

 synthesis, 



chemical, 438 



enzymatic, 438-442 

 unitarian view of action, 433-434 

 Thiamine pyrophosphate enzymes, reac- 

 tions catalyzed by, 430 



Thiamine triphosphate, 437 

 activity of, 443 



Thiocaine, as anesthetic, 9 



Thiochrome, in thiamine estimation, 

 448-449 



Thiochrome pyrophosphate, 449 



Thioctic acid, see Lipoic acid 



5,8-Thioctic acid, 583 



Thiodiphenylamine, vitamin A and, 505 



Thioformamide, 



in thiamine biogenesis, 447 



in thiamine synthesis, 419-420 



Thiosemicarbazide, pj^idoxamine and, 

 291 



Thiouracil, 57, 174, 284 



effect on thyroid gland, 40-41 



Thiourea, pteroylglutamic acid and, 174 



Threonine, 



effect in pteroylglutamic acid defi- 

 ciency, 139, 174 

 in purine synthesis, 130 

 in sulfanilamide requirement, 76-77 

 requirement for, 279 



Threonine deaminase, coenzyme of, 237- 

 238 



Thymidine, 130, 156 

 Aminopterin and, 158 

 citrovorum factor and, 110 

 effect in pernicious anemia, 140 

 in sulfonamide reversal, 127-128 

 pteroylglutamic acid and, 125 



Thymine, 33, 130, 134, 135-136, 150, 156 

 Analogs, as inhibitors, 150 

 effect in pernicious anemia, 140 

 effect in pteroylglutamic acid defi- 

 ciency, 139-140, 187, 209 

 in growth of microorganisms, 124-126 

 in pteroylglutamic acid assay, 167 

 in sulfonamide reversal, 68, 70 

 synthesis from serine and glycine, 138 



Thymine glyefol, 114 



Thyroid, lyxoflavin and, 588 



Thyroid gland, p-amino benzoic acid 

 and, 40-41, 57 

 sulfaguanidine and, 40 



Thyrotoxicosis, p-aminobenzoic acid 

 and, 84-85 



Thyroxine, 41, 57, 174 



jo-aminobenzoic acid and, 64-65 

 effect on thiamine requirement, 474 



