BACTERIOPHAGE I5 



plied to the study of the early phases of phage production should yield 

 very valuable information. 



What wdll the "intermediates" of phage reproduction, if any, be 

 like? Will they disclose the structure of the hereditary material rep- 

 resented by the postulated genetic units of replication? The recent dis- 

 covery of an osmotic membrane around the phage particle ( i ) suggests 

 that the latter may consist of both genetic and non-genetic specific 

 materials; caution will be necessary in distinguishing between the two. 

 Nevertheless, it is not unreasonable to hope that this line of work will 

 bring us one step closer to our ultimate goal, the identification of the 

 elementary "replicating units" of biological material and the clarifica- 

 tion of their mode of reproduction. 



LITERATURE CITED 



1. Anderson, T. F. Bot. Rev., 1949, 15, 464. 



2. Bernal, J. D. and Fankuchem, I. /. Gen, Physiol., 1941, 25, 111. 



3. Cohen, S. S. Bad. Rev., 1949, 13, 1. 



4. Delbriick, M. 7. Bad., 1945, 5o, 151. 



5. Delbriick, M. Biol. Rev., 1946, 21, 30. 



6. Delbriick, M. and Bailey, W. T., Jr. Cold Spr. Harb. Sympos. Quant. Biol., 1946, 



11, 33- 



7. Delbriick, M. and Luria, S. E. Arch. Biochem., 1942, 1, 111. 



8. Doermann, A. H. Carnegie Institution of Washington Yearbook, 1948, 47, 176. 



9. Ibid., 1949, 48 (in press). 



10. Dulbecco, R. Nature, 1949, 163, 949. 



11. 7. Bad., 1950, 59, 329- 



12. Foster, R. A. C. 7. Bad., 1948, 56, 795. 



13. Henle, W. and Henle, G. 7. Exptl. Med., 1949, 9o, 23. 



14. Henle, W., Henle, G. and Rosenberg, E. B. 7. Exptl. Med., 1947, 86, 423. 



15. Hershey, A. D. Genetics, 1946, 31, 620. 



16. Hershey, A. D. and Rotman, R. Proc. Natl. Acad. Sc, 1948, 34, 89. 



17. Genetics, 1949, 34, 44. 



18. Hoyle, L. Br. J. Exptl. Path., 1948, 29, 390. 



19. Hyden, H. Cold Spr. Harb. Sympos. Quant. Biol, 1947, 12, 104. 



20. Kelner, A. Proc. Nat. Acad. Sc, 1949, 35, 73. 



21. Latarjet, R. 7. Gen. Physiol, 1948, 31, 529. 



22. Lauffer, M. A., Price, W. C. and Petre, A. W. Adv. EnzymoL, 1949, 9, 171. 



23. Luria, S. E. Genetics, 1945, 3o, 84. 



24. Proc. Nat. Acad. Sc, 1947, 33, 253. 



25. Luria, S. E. and Dulbecco, R. Genetics, 1949, 34, 93. 



26. Luria, S. E. and Latarjet, R. 7. Bact., 1947, 53, 149. 



27. Luria S. E. and Gunsalus, I. C. (to be published). 



28. Luria, S. E. and Human, M. L. 7. Bact., 1950 (in press). 



29. Lwoff, A. and Gutmann, A., C. R. Acad. Sc, 1949, 229, 679. 



30. Monod, J. and Wollman, E. Ann. Inst. Pasteur, 1947, 73, 937. 



31. Pauling, L. 7. Am. Chem. Soc, 1940, 62, 2643. 



32. Putnam, F. W. Science, 1950, 111, 481. 



33. Wright, S. Physiol. Rev., 1941, 21, 487. 



