82 



II. FUNDAMENTAL STRUCTURE OF PROTOPLASM 



also by a number of other workers with other viruses, but such views 

 would of course be improper. On the contrary, Chu et al. (88) consi- 

 dered the filamentous forms of influenza virus as a stage in the multi- 

 plication of the virus, the spheroid possibly representing the mature 

 ''resting" virus, which lengthens in the host cell to a filamentous 

 •entity and fragments transversely to form the spheroid again, a view 

 which may also be unreasonable. 



2. Particles Elusive in Electron Micrography 



Angulo and his collaborators (89) examined various materials from 

 a patient with tropical treponematosis, a non-viral disease, with elec- 

 tron microscope and found particles of filamentous forms resembling 

 the virus of influenza and Newcastle disease as well as various globular 

 paticles like those of influenza, poliomeylitis or pox group. Moreover, 

 Murphy and Bang (90) have shown in electron micrographs that in a 

 normal chick chorio-allantoic membrane cell "normal" filaments are 

 seen everywhere. They demonstrated how much normal filaments 

 resemble those of influenza. If the nature of virus particles is actually 

 as hitherto discussed, such findings will be only natural. Neverthe- 

 less, rather strange to say, it seems commonly believed that particles 

 peculiar to viruses are proved only with virus-infected tissues, the 



Fig. 12. Virus-like particles in a red blood cell. Blood cell is photo- 

 graphed in Ringer's solution. Some particles appear to have a tail 

 like a tadpole. 



