VII. THE MODE OF VIRUS MULTIPLICATION 97 



On the contrary, if the protoplasm exhibits a stronger effect than 

 the virus, the latter will be altered to become idential with the former 

 in its structure and will be fused into it. In such a case the virus 

 may be said to be assimilized by the cell, while in case of the occur- 

 rence of virus multiplication the protoplasm may be said to be assimi- 

 lized by the virus. 



In a study of a strain of phage adsorbed to a resistant bacterial 

 mutant, Henry and Henry (121) found that the phage disappears with- 

 out exerting any detectable effect on the host. Even in the same sample 

 of virus particles, some virus particles may get the upper hand of the 

 cells and can induce replica in them, while some other particles may fail 

 to prevail over them because of their weak structure. The same may 

 hold true for host cells, and some cells with high susceptibility may 

 be assimilized by a virus, while others with less susceptibility may 

 not be effected by the same virus. 



If the polypeptide chains of protoplasm protein are in a stretched 

 state and in a protein moleclue thus stretched, which is situated on 

 the surface of the protoplasm, the rearrangement of polar groups is 

 raised by a virus, which has adsorbed onto the protein, in such a 

 manner that the spatial arrangement of polar groups in the protein 

 becomes complementary to that of the virus, then the protein thread 

 situated in the next place is in turn to rearrange its polar groups, 

 thus the transmission of the viral pattern being established. In such 

 a transmission, the pattern must be alternately reverse, that is, the 

 replica is to be produced in every second chain as shown in Fig. 7 

 and 9. However, if the viral template possesses a pattern in which 

 every two polar forces having opposite signs are always arranged in a 

 symmetrical position as indicated in these Figs., the replica, if turned 

 over, must be equal to the template. 



If the template protein has not such a regular structure, the 

 replica is naturally different from the template. It is, however, hardly 

 conceivable that such two types of patterns are actually induced in 

 the protoplasm. 



On the other hand, Bergmann (122) claimed that a regular repeti- 

 tion is present in the amino acid sequence of a protein. If polar 

 groups are so arranged in a polypeptide chain as to make the replica 

 equal to the turned-over template, such a regular repetition in the 

 sequence should be expected. It is believed by a number of workers 

 that amino acid residues in the protein molecules are not arranged 

 in a random fashion (85) (110). If there exists a regular repetition 

 the same two protein molecules can combine with each other since a 

 turned-over molecule reveals the complementary structure to the other. 

 There are indeed many evidences that protein molecules of the same 



