VII. REPLICATION OF VIRUS PATTERN 107 



failure of virus to attack to and invade the cells. Presumably, the 

 culture under the peculiar condition reduced the protoplasm structure 

 of the cell inadequate to be impressed by the viral pattern. It may 

 be said that the tissue cells under this culture condition may fall into 

 a state comparable to that of the "aged" bacteria, while the cells 

 may be rejuvenated by the addition of beef embryo extract to become 

 capable of achieving the rearrangement of polar groups in response to 

 the viral pattern. 



To sum up, a virus can multiply in a cell even when the cell is 

 in a "dead" state, if the rearrangement of polar groups in the cell 

 protoplasm responding to the viral pattern is possible, while even 

 viable cell cannot support the viral growth if the cell is unable to 

 respond the viral pattern. 



The virus activity may be determined by the spatial arrangement 

 of polar groups, which in turn may be chiefly dependent upon the 

 manner of distribution of amino acid residues, so that certain differ- 

 ences in the amino acid composition may be found between host cell 

 protoplasm and the virus derived from it. As already pointed out this 

 is said sometimes true. If a change like transamination or transpepti- 

 dation took place in the protoplasm when its structure was enforced 

 to alter in response to the template of the virus, some amino acids 

 would appear as if they were newly synthesized. It may be unreason- 

 able, therefore, to conclude that virus was newly synthesized from 

 amino acids even when the amino acid composition of the virus was 

 demonstrated to be evidently different from that of the protoplasm of 

 host cells. 



