Chapter IX 



Lysogeny 



FRAN901S Jacob and Elie L. Wollman 

 Service de Physiologie microbienne, Institut Pasteur, Paris, France 



I, Introduction 319 



II. Historical Development of Lysogeny 321 



A. Discovery and Criteria of Lysogeny 321 



B. Concept of Prophage 321 



III. Detection and Occurrence of Lysogeny 323 



IV. Phage Production by Lysogenic Bacteria 324 



A. Spontaneous Production 324 



B. Induction of Phage Production in Lysogenic Bacteria 326 



C. Factors Controlling Induction 326 



1. Genetic Factor 328 



2. Inducing Agents 328 



3. Environmental Factors 329 



D. Mechanism of Induction 330 



V. Properties of Lysogenic Bacteria 331 



A. Infection of Lysogenic Bacteria with Phages Homologous or Closely 

 Related to the Prophage: Immunity and Incompatibility 331 



B. Infection with Unrelated Phages 332 



C. Lysogenic Conversions 334 



VI. Characters of Temperate Phages 335 



A. General Properties 335 



B. Action of Temperate Phages on Bacterial Metabolism 336 



C. Genetics of Temperate Phages 336 



D. Prophage Mutations: Defective Lysogenic Bacteria 337 



Vn. Lysogenization 339 



A. Phenotypic Aspects of Lysogenization 339 



B. Genetics of Lysogenization 340 



VIII. Genetic Determioism of Lysogeny 341 



A. Limited Number of Prophages per Cell 342 



B. Chromosomal Location of the Prophage 342 



C. Specific Locations of DiiJerent Prophages 344 



D. Nature of the Prophage 344 



IX. Temperate Phages aa Genetic Vectors 345 



X. Lysogeny and Latency of Viruses 347 



References 349 



I. Introduction 



The clearest manifestation of bacteriophage action and, consequently, the 

 one which was first observed and thereafter received the greatest attention, 



319 



