Contents 



Contributors to Volume 1 v 



Contents of Volume 2 xiii 



Contents of Volume 3 xiv 



Preface xv 



I. The Problems of Virology by F. M. Burnet and W. M. Stanley 1 



I. Introduction 1 



II. The Double Approach 2 



A. The Infective Particle 2 



B. The Virus-Host Cell Relationship 8 



References 14 



n. Structural and Chemical Architectiu-e of Host Cells with Special 



Reference to the Synthesis of Polymers by Seymour S. Cohen 15 



I. Introduction 17 



A. Historical Notes 17 



B. The Metabolic Machinery and Virus Infection 18 



C. Possible Contributions of the Host Cell to the Synthesis of 

 Viral Polymers 25 



D. On the Origin and Cellular Relations of the Viruses 27 



II. Cellular Organization 28 



A. On the Cell in General 28 



B. The Composition of the Nucleus 30 



C. Cytoplasmic Structures 53 



III. The Distribution of Metabolic Function 69 



A. Methodological Notes 69 



B. Tables of Enzyme Distribution 71 



C. Enzymatic Systems of Nuclei 75 



D. Enzymatic Systems of Cj^oplasm 81 



E. Enzymatic Systems in the Microsomal Fraction 86 



F. Enzymatic Activities of Cell Sap 87 



G. Polymer Synthesis in Cytoplasm and Nucleus 88 



IV. Patterns of Polymer Synthesis 103 



A. Exponential Growth 103 



B. Differentiated Cells 104 



C. Synchronous Cultures 107 



D. Pathological Systems 109 



E. Unbalanced Growth Ill 



F. Syntheses with Abnormal Metabolites 118 



G. Problems of Turnover 120 



7^(5' 



vu 



