CONTENTS XI 



A. Physicochemical Properties 507 



B. Chemical Composition of Inclusion Body Proteins 510 



III. Chemical Composition of Virus Particles 513 



Keferences 521 



X. The Scope and Limitations of Immunological Methods in the 

 Characterization and Functional Study of Viruses by F, M. 



Burnet 525 



I. Introduction 525 



II. The Concepts of Immunological Specificity 527 



III. Aggregation Reactions in Virology 530 



A. Precipitin Reactions 531 



B. Complement Fixation 533 



C. Fluorescent Antibody Techniques 534 



IV, The Process of Virus Neutralization 534 



A. Neutralization of Bacterial Viruses 534 



B. Neutralization of Plant Viruses 537 



C. Neutralization of Animal Viruses by Immune Serum 538 



References 546 



XI. The Reproduction of Viruses: A Comparative Survey by S. E. 



LuRiA 549 



I. Virus Infection as Infective Heredity 549 



A. Virus Multiplication, Cell Multiplication, and Cell Growth 549 



B. Virus as Genetic Determinant 551 



C. Virus Replication and Virus Maturation 551 



II. Multiplication of Bacteriophage 553 



A. The Nature of the Replicating Phage Material 553 



B. Infectious DNA from Phage Particles 554 



C. Kinetics of Replication of Vegetative Phage 555 



D. Functions of the Phage Genome 555 



E. Phage Maturation and Infective Heredity 558 



III. Multiplication of Tobacco Mosaic Virus 559 



A. RNA as the Initiator of Infection 559 



B. TMV Protein and Virus Maturation 560 



C. Other RNA Viruses 561 



IV. Multiplication of Animal Viruses 562 



A. Myxovirus Group 562 



B. Other Viruses 562 



V. Virus Multiplication, Cell Function, and Cell Organization. . . 563 



A. Restatement of the Dual Hypothesis 563 



B. Cell Damage and Virus Multiplication 564 



C. Viruses and Cellular Constituents 565 



References 566 



Author Index 569 



Subject Index 591 



