IV. SPECIFICITY OF ACTION 



279 



as linoleic acid, using the method of minimum dose for maximum response. 

 Hume et air found arachidonic acid doubly as effective as Hnoleic acid when 

 fed at low levels. Tests by Burr et al? indicate a slightly greater response 



TABLE II 

 Biological Activity of Unsaturated Acids and Their Derivatives 



2 E. M. Hume, L. C. A. Nunn, I. Smedley-Maclean, and H. H. Smith. Biochem. J. 

 34,379, 384 (1940). 



3 G. O. Burr, J. B. Brown, J. P. Kass, and W. O. Lundberg. Proc. Soc. Exptl. Biol. 

 Med. 44, 242 (1940). 



^S. M. Greenberg, C. E. Calbert, H. J. Deuel, Jr., and J. B. Brown, J. Nulniion 



45, 521 (1951). 

 ^ G. O. Burr, Chemistry and Medicine, p. 101. University of Minnesota Press, 1940. 

 6R. T. Holman, Proc. Soc. Exptl. Biol. Med. 76, 100 (1951). 

 ^ R. T. Holman, Proc. 3rd Conf. on Research, Atn. Meat Inst. Univ. Chicago p. 1 



(1951); Fctte n. Scifen 53, 332 (1951). 



8 P. Karrer and H. Kocnig, Helv. Chim. Acta 26, G19 (1943). 



9 G. O. Burr, M. M. Burr, and E. S. Miller, J. Biol. Chem. 97, 1 (1932). 

 i» H. M. Evans and S. Lepkovsky, J. Biol. Chem. 96, 143 (1932). 



" R. G. Sinclair, J. Nutrition 19, 131 (1940). 



12 E. M. Hume, L. C. A. Nunn, I. Smedley-Maclean, and H. H. Smith, Biochem. J. 



32, 2162 (1938). 

 " U. Tange, Sci. Papers Inst. Phys. Chem. Research (Toki/o) 20, 13 (1933). 



