VIII. EFFECTS OF DEFICIENCY 



309 



former and from 40 to 90 for the latter. In animals receiving amounts of fat 

 inadequate to effect a completely normal skin, the serum diene and tetraene 

 values were intermediate between the normal and fat-deficient groups. The 

 correlations observed between the dietary history, the serum lipids, and the 



Fig. 15 (6) 

 Fig. 15. Photomicrograph (magnification 1425X) section through the skin of a dog 

 (a) on a low fat diet and (b) after 6 months on a diet with 29% calories as fresh lard 

 substituted isocalorically for sucrose. (From Hansen and Wiese.^') 



gross changes in the animals seem to be very significant and have been 

 valuable in interpreting the results of spectral analysis of serum fatty acids 

 in human subjects. 



d. Histologic Features 



Definite alterations occur in the histologic structures of the skin of dogs 

 which have been deprived of dietary fat.^^ Changes are discernible in the 

 stratum corneum, epidermis, and dermis (see Figs. 15a and 15b; see also 



