TABLE XI 

 Specificity of Compounds Related to Nicotinic Acid 



Rat 



Compounds 



Man 



Urinary excretion Growth 



Dog 



Substitution on the Ring 



Nicotinic acid (3-carboxypyridine) + (!)"■ '' 



Picolinic acid (2-carboxypyridine) 



Isonicotinic acid (4-carboxy- 

 pyridine) 



Quinolinic acid (2,3-dicarboxy- + (7, 8) 



pyridine) 



Dinicotinic acid (3,5-dicarboxy- ± (15) 



pyridine) + (16) 



Isocinchomeronic acid (2,5-di- 

 carboxypyridine) 



Nipecotic acid (hydrogenated nico- 

 tinic acid) 



2,6-Diniethylnicotinic acid +(16) 



±(15) 



2,6-Dimetliyl-3,5-dicarboxy- db (16) 



pyridine 



6-Methylnicotinic acid 



3-MethyIpyridine ± (16) 



3-Aminopyridine ± (16) 



3-Cyano pyridine 



A'' Substitutions 

 N'-Methylnicotinamide 



Trigonelline (betaine of nicotinic (16, 22) 



acid) 

 Nicotinamide glucosidoiodide 



Modifications of Carboxyl Group 



+ (2-4) 



0(3) 



+ (2, 9, 10) 

 0(3) 



+ (9) 



0(3) 



(5) 



+ (10-12) 



±(12) 



+ (6) 

 0(6) 

 0(6) 



+ (13) 

 (6, 14) 



(6. 17) 



+ (6) 



" + = active; = no nicotinic acid activity; ± = questionable; urinary excretion = increased excre- 

 tion of nicotinic acid metabolites, usually NLmethylnicotinamide, after administration of the compound. 

 *■ Numbers in parentheses refer to appropriate references. 



518 



