V. SPECIFICITY OF ACTION 519 



TABLE XII 



Compounds Related to or Derived from Tryptophan. 



Ability to Substitute for Nicotinic Acid 



Rat 



Urinary nicotinic 

 Compounds acid excretion Growth 



DL-Tryptophan +(9,43-45)"''' +(46) 



Acetyl -L-tryptophan 



Indole-3-pyruvic acid 



Indole-3-proprionic acid 



Indole-3-butyric acid 



Indole-3-acrylic acid 



Indole-3-acetic acid 



Indole 



Naphthylacetic acid 

 L-Kynurenine 



N-Formylkynurenine 

 Acetylkynurenine 

 Kynurenic acid 

 Xanthurenic acid 

 Anthranilic acid 



3-Hydroxyanthranilic acid 



3 , 4-Dihydroxyanthranilic acid 



N-Formylanthranilic acid 



" + = active in substituting for nicotinic acid; = not active. 

 * Numbers in parentheses refer to appropriate references. 



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