590 PANTOTHENIC ACID 



Page 



VIII. Occurrence in Food 634 



A. Assay Values in Foods, Feeds, Tissues, and Miscellaneous Materials 634 



B. Effect of Various Factors on Pantothenic Acid Distribution. . . . 634 



1. Effect of Variety, Species, and Breed 635 



2. Effect of Environment during Period of Growth 635 



3. Effect of Germination and Embrj'onic Development 636 



4. Effect of Diet on Tissue Composition 636 



5. Effect of Storage 637 



6. Effect of Heat and Cooking 637 



7. Effect of Stage of Lactation 638 



C. Distribution of Coenzyme A 638 



IX. Effects of Deficiency 649 



A. In Animals 649 



1. Rats 650 



2. Chicks 658 



3. Turkeys 661 



4. Ducks, Pigeons, and Other Fowl 661 



5. Dogs 663 



6. Guinea Pigs 664 



7. Swine 664 



8. Cattle and Sheep 666 



9. Monkeys 667 



10. Mice 667 



11. Other Species 668 



B. In Man 669 



1. Introduction 669 



2. Summary of Pathological Findings in Animals Fed Diets Deficient 



in Pantothenic Acid 669 



3. Pathological Lesions in Human Beings Suggestive of a Deficiency of 

 Pantothenic Acid 670 



C. In Microorganisms 678 



X. Pharmacology 680 



XL Requirements and Factors Influencing Them 682 



A. Of Animals 682 



1. Minimal Levels 682 



2. Factors Influencing Requirements 683 



B. Of Man 687 



1. Pantothenic Acid Content of Foods 687 



2. Urinary Excretion and Blood Levels of Pantothenic Acid in Human 

 Beings 688 



3. Approximate Pantothenic Acid Requirement of Man as Based on 



the Known Requirement of the Experimental Animal 691 



4. Toxicity of Pantothenic Acid 692 



5. Summary 693 



