758 



SUBJECT INDEX 



isolation of, 454-456 



methylation of, 516-517 



solubility, 466 



stability, 466 



synthesis, 476-478 



toxicity of, 571-572 

 Niamid, see Niacin 

 Nicotinamide, see also Niacinamide 



effect on choline oxidase, 35 



methylation of, 23, 26, 32, 33 

 Nicotinamide methochloride, see N'- 



methylnicotinamide 

 Nicotinamide methylkinase, 32 

 Nicotinamide mononucleotide, 



biosynthesis of, 505-506 



inorganic phosphate and, 498 



significance of, 494 

 Nicotine, 



niacin synthesis from, 474 



resemblance to choline, 123 

 Nicotinic acid, 592, see also Niacin 



burning feet syndrome and, 676, 677 



effect in choline deficienc.y, 79 



fatty liver and, 80, 82-83 



gelatin and, 94 



methylation of, 23, 32 



perosis and, 94, 97 

 Nicotinuric acid, 457 



differential assaj^ of, 536 

 Nitrate, pantothenic acid and, 636 

 Nitrogen metabolism, 



in pellagra, 564 



pyridine nucleotides and, 502-503 

 Nitrogen mustards, 89, see also Methyl - 



bis- (/3-chloro-ethyl) -amine 

 A5.7.Norcholestadiene-3-ol, 142 



as provitamin D, 145 

 Nordihydroguaiaretic acid, fatty acids 



and, 285-286 

 Norepinephrine, methylation of, 32 

 Nucite, see Inositol 

 Nuclei, choline oxidase in, 35 

 Nucleotide pyrophosphatase, effect on 



coenzyme A, 603-604 

 Nutritional disease, in war prisoners, 

 673-677 



Obesity, choline and, 106-107 

 A9,12-Octadecadienoic acid, see Linoleic 

 acid 



A9,12,15-Octadecatrienoic acid, seeLino- 



lenic acid 

 Oleic acid, 



autoxidation of, 274 



effect on choline oxidase, 36 

 Ornithine, niacin and, 521, 522-523 

 Osteoblasts, in bone formation, 232-234 

 Osteoclasts, 234 

 Osteoid, 



in bone formation, 234, 237-238 



in osteomalacia, 241 



in rickets, 231-232 

 Osteomalacia, 234 

 Osteoporosis, 241 



in hypervitaminosis D, 264 

 Oxalacetic acid, 16, 502, 679 



pyridine nucleotides and, 499, 500 

 Oxalosuccinic acid, 511 



pyridine nucleotides and, 500 

 Oxidation, in choline deficiency, 90 

 22,23-Oxidocalciferol, 206 

 22,23-Oxidoergosterol, 206 



as provitamin D, 146 



formation, 142 

 Oxygen, effect on ergosterol activation, 

 181 



Palmitic acid, 



effect on choline oxidase, 36 

 Pancreatectomy, fatty liver and, 100-101 

 Pantetheine, 16 



in pantothenic acid assay, 632, 633 



release from coenzj'me A, 631-632 

 Pantethine, 624 



as growth factors, 613 



synthesis of, 606 

 Pantoic lactone, 627 



isolation of, 596 

 Pantothenic acid, 15-16, 17, 92, 101, 380 



acetyl, 626 



alkali stabilitj^ of, 611 



amino acid analogs of, 626-627 



biochemical systems, 598-625 



biogenesis of, 627 



burning feet syndrome and, 677 



chemistry, 591-598 



comparative requirements for, 691-692 



constitution of, 597 



deficiency symptoms, 669-670 



