CONTENTS IX 



X. Poliomyelitis and Other Neurotropic Viruses 91 



A. Nerve Cells 91 



B. Epithelial Cells and Fibroblasts 92 



C. Encephalitis 95 



XI. Tumor Viruses 95 



A. Rous Chicken Sarcoma 96 



B. Mammary Tumors of Mice 99 



C. Warts (Human Papillomas) 101 



D. Frog Adenocarcinoma 101 



XII. Discussion and Conclusions 103 



References 105 



VI. Biological Aspects of Intracellular Stages of Virus Growth by Alick 



Isaacs Ill 



I. Introduction Ill 



II. The Eclipse Phase 112 



A. Amount of Infective Virus Recoverable during the Lag 

 Period 113 



B. Attempts to Demonstrate Virus during the Lag Period by 



Its Antigenic Properties 120 



C. The Significance of Virus Recoverable during the Lag Period 1 22 



III. Development within Infected Cells of Antigens Associated with 

 Virus Multiplication 126 



A. The 30 S Complement-Fixing (Soluble) Antigen of 

 Influenza and Related Viruses 126 



B. The Hemagglutinin of Myxoviruses 129 



C. Cell- Associated Antigens of Other Viruses 132 



IV. Dynamics of the Development of Infective Virus 133 



A. Poliomyelitis Virus 133 



B. Western Equine Encephalitis Virus 134 



C. Influenza Virus 135 



D. Newcastle Disease Virus of Fowls (NDV) 136 



E. Herpes Simplex Virus 137 



F. Vaccinia Virus 137 



V. The Release of Virus from Infected Cells 138 



A. Western Equine Encephalitis and Poliomyelitis Viruses . . 138 



B. Myxoviruses 139 



C. Herpes Simplex and Vaccinia Viruses 141 



D. Mechanism of Release of Virus and Virus Filaments 142 



VI. Incomplete Virus 143 



A. Properties of Incomplete Virus 144 



B. Production of Incomplete Virus 146 



C. Partial Cycle of Virus Development Produced by Incomplete 

 Virus 149 



D. Incomplete Viruses Other Than Influenza 150 



