X CONTENTS 



VII. Conclusions 151 



References 153 



VII. Interference between Animal Viruses by R. Walter Schlesinger 157 



I. Introduction 157 



II. Definition of the Problem 158 



A. Qualitative Criteria for a Definition of Interference 158 



B. Criteria for Quantitative Analysis 160 



III. Experimental Systems 161 



A. Demonstration of Interference in Mammalian and Avian 

 Hosts 161 



B. Interference among Members of the Myxovirus Group in 



the Allantoic Membrane of Chick Embryos (CAM) 173 



C. Demonstration of Interference in Tissue Culture 181 



IV. Dynamics of Interference — Summary 182 



A. Qualitative Criteria — Specificity of Induction 182 



B. Quantitative Criteria 184 



V. Mechanisms of Interference 185 



A. Nature of Association of Interfering Virus and Cell 186 



B. Fate of the Super infecting Virus 187 



C. Perspectives 189 



References 189 



VIII. Inhibition of Multiplication by Frank L. Horsfall, Jr 195 



I. Introduction 195 



II. Prevention of Virus Infection 198 



A. Alteration of Extracellular Environment 198 



B. Inactivation of Extracellular Virus 199 



C. Alteration of Host Cells 201 



III. Inhibition of Intracellular Multiplication 201 



A. Inhibition during Latent Period 202 



B. Resume of Inhibition during Latent Period 211 



C. Inhibition after Latent Period 211 



IV. Inhibition of Release 213 



V. Chemical Structure and Inhibitory Activity 214 



A. Benzimidazoles and Derivatives 214 



B. Amino Acids and Derivatives 217 



C. Purine and Pyrimidine Analogs 218 



D. Compounds Affecting Oxidative Metabolism 218 



VI. Modification of Cell Damage 219 



VII. Current Status of Inhibition of Multiplication 220 



References 222 



