THE MORPHOLOGICAL APPROACH 



105 



TABLE II 

 Location of Virus and Cellular Lesion in Some Virus Tumors 



Virus 



Location in cell 



Predominant lesion 



Rous chicken sarcoma Surface, occasional intra- 

 cytoplasmic vesicle 



Mammary tumor of Cytoplasmic vesicles, 



mice microvilli 



Shope fibroma 



Human warts 



Cytoplasmic 



Nucleus, entire cell when 

 keratinization takes place 



Frog adenocarcinoma Cytoplasm, nucleus, 

 microvilli 



Paranuclear hypertrophy 



Large cytoplasmic 



"inclusion" in some strains 



Cytoplasmic granular masses, 

 nucleolar changes 



Eosinophilic intranuclear 

 inclusion 



Intranuclear inclusion bodies 

 in about 1/3 of tumors 



Keferences 



Ackerman, W. W., Rabson, A., and Kurtz, H. (1954). J. Exptl. Med. 100, 437. 



Adams, W. R., and Prince, A. M. (1957). J. Exptl. Med. 106, 617. 



Algire, G. (1957). Federation Proc. 16, 601. 



Amies, C. R. (1938). J. Pathol. Bacteriol. 47, 205. 



Andrewes, C. H. (1939). J. Pathol. Bacteriol. 48, 225. 



Andrewes, C. H., Bang, F. B., and Burnet, F. M. (1955). Virology 1, 170. 



Anderson, R. (1940). Am. J. Pathol. 16, 137. 



Archetti, I. (1955). Arch. ges. Virusforsch. 6, 29. 



Baker, J. R. (1957). Symposia Soc. Exptl. Biol. 10, 1. 



Bang, B. G., and Bang, F. B. (1957). J. Ultrastructure Research 1, 138. 



Bang, F. B. (1950). Bull. Johns Hopkins Hosp. 87, 511. 



Bang, F. B. (1953a). Bull. Johns Hopkins Hosp. 92, 291. 



Bang, F. B. (1953b). Bull. Johns Hopkins Hosp. 92, 309. 



Bang, F. B. (1954). J. Appl. Phys. 25, 1462. 



Bang, F. B. (1955a). Federation Proc. 14, 619. 



Bang, F. B. (1955b). Ann. Rev. Microbiol. 9, 21. 



Bang, F. B., and Andervont, H. B. (1953). J. Appl. Phys. 24, 141. 



Bang, F. B., and Gey, G. O. (1949). Proc. Soc. Exptl. Biol. Med. 71, 78. 



Bang, F. B., and Gey, G. O. (1951). Trans. N. Y. Acad. Sci. 13, 324. 



Bang, F. B., and Gey, G. O. (1952). Bull. Johns HojMns Hosp. 91, 427. 



Bang, F. B., and Haley, R. (1958). J. Natl. Cancer Inst. 20, 329. 



Bang, F. B., and Isaacs, A. (1957). In "Nature of Viruses" (G. E. W. Wolstenholme and 



E. C. P. Millar, eds. for Ciba Foundation), p. 249. Churchill, London. 

 Bang, F. B., Levy, E., and Gey, G. O. (1951). J. Immunol. 66, 329. 

 Bang, F. B., Vellisto, I., and Libert, R. (1956a). Bull. Johns Hopkins Hosp. 98, 255. 

 Bang, F. B., Andervont, H. B., and Vellisto, I. (1956b). Bull. Johns Hopkins Hosp. 98, 



287. 



