SYNTHESIS OF A NEW DIQUINOLIN. 



39 



Experiment I. — Rabbit weighed 920 grms. 

 Dose = 0'108 grm. per kilo of body- 

 weight. 



Date. 



Feb. 18th 



Feb. 19th 



Time. 



TemperatureiTemp. of 

 ; of animal. I room. 



4.25 P.M. 102° F. 72° F. 



4.30 " Injected, i — 



5.30 " 99-8° F. I — 



6.00 " '■ 99-0° F. 72° F. 



7.30 " 97-8° F. I — 



8.00 " 96-9° F. ! — 



8.30 " 96-5° F. 71° F. 



9.00 " 96-8° F. — 



9.30 " 98-0° F. 70° F. 



10.00 " 99-2° F. I — 



10.30 " 99-0° F. I 67° F. 



9.30 A.M.' 101-2° F. 65° F. 



Experiment II. — Rabbit weighed 1-5 kilo. 

 Dose = 0-066 grm. per kilo of body- 

 weight. 



Date. 



Feb. ISth, 



Feb. 19th 



Time. 



Temperature Temp, of 



of animal. 



4.25 P.M. 

 4.30 " 

 5.30 " 

 6.00 " 

 7.30 " 

 8.00 " 

 8.30 " 

 9.00 " 

 9.30 " 

 10.00 " 

 10.30 " 

 9.30 a.m. 



102-2° F. 

 Injected. 

 100-2° F. 



99-6° F. 



99-0° F. 



98-5° F. 



98-0° F. 



99-8° F. 



99-8° F. 

 100-2° F. 

 100-0° F. 

 100-8° F. 



72° F. 



72° F. 



71° F. 



70° F. 



67° F. 

 65° F. 



The antiseptic properties of the base were roughly tested on beef-broth, etc. A few 

 grains added to urine or to beef-broth prevented decomposition for several weeks, while 



