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INTERMEDIARY METABOLISM AND GROWTH 



TABLE 1 



PYRIDINE NUCLEOTIDE DEHYDROGENASES 



Reaction 



Source 



Cofactor 



I. Enzymes oxidizing alcohols 



1. ethanol -^ acetaldehyde 



2. D-sorbitol —- fructose 



D-mannitol- 1 -phosphate — » 



phosphate 



NiO-hydroxymethyl-THFA 



THFA 



vitamin A -^ retinene 



a-glycerophosphate —>■ dihydroxy- 



acetone phosphate 



3a, 17a, 20 P, 2i-tetrahydroxypregnane-i I 



one — > 3a, 17a, 2 1 -trihydroxypregnane- 1 1 



2o-dione (^-cortolone) 



UDP-glucose —> UDP-glucuronic 



L-histidinol —>■ L-histidinal 



10. UDP-glucose -^ UDP-galactose 



1 1. xylitol -^ L-xylulose 



12. xylitol —-> D-xylulose 



13. ribitol —>■ D-ribulose 



14. sorbitol -^ D-glucose 



15. sorbitol —> sorbose 



16. iditol —> L-sorbose 



1 7. threitol —>■ L-erythrulose 



//. Enzymes oxidizing cyclic compounds 



18. myoinositol —^ 2-ketoinositol 



19. shikimic — > 5-dehydroshikimic 



20. quinic —> 5-dehydroquinic 



21. (3a-hydroxysteroid -^ 3-ketosteroid) of 

 Cj9 or C21 (saturated at positions 4 and 5) 



'21a. 3ri-hyclroxysteroid - 

 1 7p-hydroxysteroid 



3-ketosteroid 

 * 1 7-ketosteroid 



22. inosinic -^ xanthosinic 



* (skeletons of androstane, etiocholane, 

 cholane, pregnane). 



///. Enzymes oxidizing hydroxyacids 



23. L-lactic -^ pyruvic 



24. L-malic -^ oxalacetic 



25. L-malic -» pyruvic + CO2 



26. glycolic — > glyoxylic 



27. fi-hydroxyisobutyric — > a-methylmalonic 

 semialdehyde 



28. L-gulonate — » D-glucurono-v-lactone 



29. a-acetolactate — > oc-ketoisovalerate 



muscle 



DPN 



ubiquitous 

 ubiquitous 

 ubicjuitous 

 spinach leaves 



ubiquitous 



liver 



yeast 



DPN 

 DPN 

 TPN 

 DPN 



DPN 

 TPN 

 TPN 



