12 



INTERMEDIARY METABOLISM AND GROWTH 



Table /, continued 



Reaction 



Source 



Cof actor 



59. saturation of double bond of A"*-3-keto- 



steroids (cortisone, Cortisol, DOC, compound 

 B, compound S, aldosterone, progesterone, 

 I i-ketoprogesterone, 1 7-hydroxyprogesterone, 

 testosterone, adrenosterone, cholestenone) liver 



TPNH 



VII. 2 RSH -^ RSSR 



60. 2 GSH ^ GSSG 



61. 2 cysteine — > cystine 



62. lipoic (reduced) -^ lipoic (oxidized) 



ubiquitous 



yeast 



ubiquitous 



TPN 

 DPN 

 DPN 



VIII. Transhydrogenase 



63. TPNH + DPN -^ TPN + DPNH 



Pseudomonas, liver, 

 muscle, kidney, 

 heart 



IX. Hydroxylating enzymes 



64. L-kynurenine — > 3-hydroxykynurenine 



65. 2i-hydroxylations 



I ya-hydroxyprogesterone -^ 



17, 2i-dihydroxyprogesterone (compd. S) 

 progesterone -^ DOC 

 iiP-hydroxyprogesterone -^ corticosterone 



I I [3, lya-dihydroxyprogesterone — > 

 compd. F 



66. phenylalanine -^ tyrosine (hydroxylation) 



67. II [i-hydroxylation (deoxycortisol 

 DOC -^ corticosterone) 



68. squalene — > lanosterol 



Cortisol, 



69. /^-hydroxyphenylpyruvic — > homogentisic 



70. imidazole acetic — + formiminoaspartic 



71. nonspecific aromatic hydroxylase (produce 

 phenols) 



72. dealkylating enzymes 

 (3-methyI-4-monomethylaminoazobenzene ■ 

 3-methyl-4-aminoazobenzene) , 

 (methylamphetamine, meperidine, methyl- 

 aniline, quinacrine, diacetylmorphine, 

 methadone, codeine) 



73. deaminating enzymes 

 (amphetamine -^ /;-hydroxyamphetamine) 



74. estradiol — > 6,3-hydroxyestradiol 



liver mito- 

 chondria 

 adrenal 

 microsomes + 

 supernatant 



soluble fraction 

 of liver 

 adrenal 

 mitochondria 

 soluble fraction 

 of liver 

 liver 

 Pseudomonas 



TPNH, O2 

 TPNH, O2 



TPNH, O2, 

 Fe^^ 

 TPNH, O, 



TPNH, O2 



TPNH? 

 DPNH, O, 



liver TPNH, O^, 



Fe"^ 

 liver microsomes TPNH, O2 



liver microsomes TPNH, O2 

 liver microsomes TPNH 



