CONTENTS XV 



III. Proteins and Amino Acids 896 



(a) Composition, 896 - (b) Protein metabolism, 897 - (c) Amino acid metab- 

 olism, 899 - 



IV. Nucleic Acids and Nucleoproteins 902 



(a) Composition, 902 - (b) Metabolism, 906 - 



V. Other Metabolic or Compositional Features of Neoplastic Tissues . . . 913 

 (a) Enzymes, 913 - (b) Minerals, 915 - (c) Other metabolic features, 915 - 



VI. Summary 916 



Literature 919 



Chapter 13. Action of Certain Antimetabolites as Mitotic Poisons, by 

 John J. Biesele 926 



I. Introduction 926 



II. Preprophasic Inhibition 927 



(a) Antifolic acids, 929 - (b) Antiglutamines, 930 - (c) Purine and pyrimidine 

 analogues, 930 - (d) Nucleosides, 935 - (e) Nucleotides, 936 - (f ) Amino acids 

 and analogues, 936 - 



III. The Poisoning of Chromosomes 937 



(a) Amino acids, 938 - (b) Antifolic acids, 939 - (c) Purines and pyrimidines, 

 939- 



IV. Poisoning of the Spindle 941 



(a) Antifolics, 943 - (b) Nucleic acid components and analogues, 944 - 



V. Conclusion 946 



Literature 947 



Chapter 14. Growth and the Aging Process, by Warren Andrew .... 952 



Conclusion 969 



Literature 971 



Subject Index 973 



