CONTENTS Xni 



Chapter 8. Wound Healing as a Problem of Growth, by Wesley W. 



Washburn Jr 664 



I. Introduction 664 



II. The Stimulus for Wound Healing 666 



III. Wound Closure 669 



(a) Contracture, 669 - (b) Intussusceptive growth, 671 - (c) Growth from the 

 wound edge, 671 - 



IV. Epithelialization 674 



(a) Retraction of the epidermal edge, 675 - (b) Detachment of the epidermis 

 from the basement membrane, 675 - (c) Migration of epithelium over the 

 wound surface, 675 - (d) Cessation of cell movement and reattachment, 680 - 



V. Chemical Changes Associated with Epithelialization 683 



VI. Source of Granulation Tissue ". . 688 



VII. Fibroblastic Proliferation 691 



VIII. The Chemistry of Granulation Tissue 693 



IX. Alkaline Phosphatase 698 



X. Role of Sulfur in Wound Healing 699 



' XI. Summary 701 



Literature 703 



Chapter 9. Nitrogen Metabolism and Growth, by Hugh Clark . . . .712 



I. Introduction 712 



(a) Growth and development, 712 - (b) Metabolism of nitrogen compounds, 

 715- 



II. Nitrogen Metabolism in Relation to Aspects of Development . . . . 716 

 (a) Gametogenesis and fertilization, 717 - (b) Cleavage and blastulation, 

 721 - (c) Observations of protozoa, 725 - (d) Gastrulation, 727 - (e) Organo- 

 genesis, 727 - I. Protein Synthesis, 728 - a. Chemical limitations, 728 - 



b. Cytological mechanisms, 729 - c. Relationship with yolk storage, 729 - 

 2. Growth Regulation, 730 - a. Differential growth, 730 - b. Cessation of 

 growth, 731 - c. Genetic control of growth, 733 - 3. Energy Sources of 

 Development, 735 - a. General, 735 - b. Succession of energy sources, 736 - 



c. Nitrogen metabolism in cleidoic eggs, 738 - 



III. General Summary 741 



Acknowledgements 743 



Literature 744 



Chapter 10. Plant Growth, by Kenneth V. Thimann 748 



I. General Characteristics of Plant Growth 748 



II. Definitions 751 



III. The Measurement of Growth 753 



(a) General, 753 - (b) The use and measurement of auxins, 755 - (c) Assays 



for other growth factors, 758 - 



IV. Chemistry of the Growth Substances 760 



