METABOLIC CHANGES 



613 



TABLE 9 



FUNCTIONS OF ALKALINE PHOSPHATASE DURING REGENERATION 

 SUMMARY OF RESULTS 



Example 



Reference 



(a) During regressive processes 



{i) Positive correlation 

 Amphibian limb-regeneration Ghiretti, 1950; Karczmar and Berg, 1951 



Mammalian wound-healing 



Danielli et al., 1946; Balazs and Holm- 

 ] gren, 1950; Utsunomiya et al., 1952, 

 ( 1953; Valentine, 1955 

 Mammalian bone-regeneration Bourne, 1948 



Mammalian nerve: Wallerian degeneration Hollinger et al., 1952 



(histochemical evidence) 

 General adaptation response, produced by \ Kochakian and Bartlett, 1948; 



adrenal cortical hormones ( Taleisnik, 1953 



Mammalian liver: atrophy during starva- \ Wachstein, 1945; Ely and Ross, 1951; 



tion / Rosenthal et al., 1950, 1951 



Embryonic development : cell-degeneration Yao, 1950 



{ii) Negative correlation 



Enzyme inhibited by SH-compounds and \ Fell and Danielli, 1944; Gould and 

 other R-phase conditions / Gold, 1951; Rosin, 1952 



(b) Association with cell-proliferation 



{i) Positive correlation 



Mammalian skin-regeneration Firket, 1950 



Mammalian liver-regeneration Oppenheimer, 1946 

 Mammalian nerve-regeneration: Schwann- Hollinger et al., 1952 



cells 



Tissue culture experimental wound De Lustig and Sacerdote, 1954 



Tissue culture : normal proliferation Willmer, 1942b 



Mammalian liver: normal growth Wachstein, 1945 



Mouse tissues (nuclei): normal growth Brachet and Jeener, 1948 



(ii) Negative correlation 

 Mammalian liver-regeneration Taleisnik, 1953 



(c) Association with differentiation 



Eisenia : body-regeneration 



Tunicates : regeneration and budding 

 (ATP-ase) 



Tadpole: tail regeneration 



Amblystorna: limb-regeneration and ontoge- 

 nesis 



Mammalian skin-healing 



Mammalian bone-healing 



Ontogenesis (enzyme-activity high in later 

 stages) 



Powell, 1 95 1 



Jaeger and Barth, 1938 



Junquiera, 1950 

 Karczmar and Berg, 1951 



\ Fell and Danielli, 1944; 



/ Danielli et al., 1946 



/ McKelvie and Mann, 1948; 



■ Fontaine et al., 1952; Buser, 



( 1948; Utsunomiya etal., 1952, 1953 



( Yao, 1950; Brachet, 1950; 



< Krugelis et al., 1952; 



( Minganti, 1954 



Literature p. 641) 



