V 



METABOLIC CHANGES 



617 



TABLE 11 



EVIDENCE FOR AN INCREASE IN OXIDATION IN LATER STAGES OF REGENERATION 



Nature of evidence 



Material 



Reference 



Increase in 02-consumption 



Regeneration accelerated by 

 increasing 0,-supply 



Regeneration retarded by Corymorpha Schechter, 1941 



restricting Oj-supply planarians Schultz, 1902 



Regeneration retarded by poi- 

 sons of the cytochrome system 



Tubularia Bassina, 1937; Moog and Spiegel- 



man, 1942 



Regeneration-rate varies with Tubularia Barth, 1937 



variations in 02-consumption AUolobophora O'Brien, 1947 



Regeneration accelerated by Hydroids 



pyocyanin and dinitro-phenol mammalian 



which speed oxygen-consump- skin 

 tion 



Rulon, 1938; Deotto, 1939 

 Finkelstein and Kovarskaja, 1936 



Loss in body weight becomes Tubifex Collier, 1947 



more rapid 



Cell-products best accelerate 

 growth in the presence of 

 abundant O, 



yeast 



Loofbourow, 1942 



Inhibition of 02-consumption 

 inhibits cell-movements 



Xenopus and hehmann et al., 1954 



mammalian liver 



1951) and the synthesis of mucopolysaccharides (Zoger, 1952), and so restricts 

 these syntheses to the P-phase. In turn, SH-compounds inhibit alkaline phos- 

 phatase (Fell and Danielli, 1944; Gould and Gold, 1951) while the oxidised, 

 -SS- form accelerates its activity (Fell and Danielli, 1944), thus restricting its 

 activity to the later, differentiation processes of the P-phase. Oxidation of GSH 

 in vivo is probably coupled with the reduction of dehydroascorbic acid to vitamin 

 C (Mapson and Goddard, 1951 ; Conn and Vennesland, 1951), which is associated 

 with GSH, in the adrenal cortex, and which increases in amount, in regenerates, 



Literature p. 64;) 



