630 



REGENERATION AND GROWTH 



TABLE 13 



ACTION OF ADRENAL CORTICOIDS ON REGENERATION 



Material 



Corticoid 



Reference 



(a) Promotion of regeneration 

 Trituriis: limb 



Mammal: liver 

 Mammal : liver 



Mammal: skin 



unspecified 



deoxycorticosterone 

 unspecified 



unspecified 



Schotte and Lindberg, 1954; 



Schotte and Chamberlain, 1955 

 I Berman ei a/., 1947; Friedgood 

 ' et al., 1950 



Taleisnik, 1954; Giberti and 

 Bianchini, 1954 



Wyburn-Mason, 1950; p. 246 



(b) JVo effect 



Triturus: limb 



Mammal : bone 



Small gastric wounds of mam- 

 mal 



Mucin-production in gut of 

 mammal 



cortisone 



Bragdon and Dent, 1954 

 Key and Odell, 1952 

 Janowitz et al., 1955 



Jennings and Florey, 1954 



(c) Inhibition 

 Triturus: limb 



Mammal: skin 



Mammal : liver 

 Mammal : bone 



Mammal : large gastric 

 wounds 



Mammal: nerve 



Mammal : reticuloendothelial 

 systein 



cortisone and deoxycor- 

 ticosterone 

 cortisone 



Manner, 1955 

 1 Billingham et al., 1951 ; Zoger, 

 ^ 1952 ; Montgomery and Green, 

 ' 1954; Gillman et al., 1955 

 ( Perez-Tamayo, 1953; Einhorn 

 I etal, 1954 



Fontaine et al., 1952 



Blunt et al., 1950 

 Janowitz et al., 1955 



( Lytton and Murray, 1954; 

 \ Thomas, 1954 

 Mene, 1953 



and macrophages in the demoHtion- and defence-period (Bourne, 1948), and its 

 depletion in this activity may explain the early, and temporary, decrease in amount 

 of the vitamin, locally (Ryvkina, 1940; Merezhinskii et al., 1954). This decrease 

 is synchronous with an increase in free SH-groups and later both trends are 

 reversed. The interaction between these two reducing agents, and their associa- 

 tion with alkaline phosphatase in the synthesis (differentiation) of connective 

 tissues has been indicated. 



Thiamine normally increases locally throughout the process of healing of rat- 

 skin (Paul et at., 1945). It is depleted by infection, which retards healing, — pos- 

 sibly for this reason. Riboflavin accelerates regeneration in Planarians (Brondsted, 

 1955, p. 104) and in rats (Bosse and Axelrod, 1948). Biotin and pyridoxin also 

 promote skin-healing in rats. Nicotinic acid speeds regeneration in Planarians 



