672 



WOUND HEALING 



Fig. 2. The same area three weeks later showing the uniform formation of granulation tissue. 



Fig. 3. The patient eight months following split-thickness skin grafting. 



Brenk (1956) has used this technique to follow the complete growth pattern of 

 granulation tissue in the rabbit ear. He found that after a latent period of approxi- 

 mately 8 days the growth curve maintained a linear relationship with time. The 

 technique employed, however, possesses several shortcomings. Since the space 

 occupied by the chamber is fixed and growth is limited to a lateral direction, 

 it is unlikely that such a long latent period which appears to be dependent 

 primarily upon vascularity of the area exists in the normal wound. If vascular loops 



