698 



WOUND HEALING 



TABLE 2 



RELATIVE CHARACTER OF THE CHANGE IN SOME CELLULAR AND NON-CELLULAR 



COMPONENTS OF MAMMALIAN DERMIS COMPARED WITH TENSILE STRENGTH 



DURING NORMAL WOUND HEALING 



MUCOPOLYSACCHARIDES 



CYSTINE ond CYSTEINE 



METHIONINE 



ALK PHOSPHATASE 



MAST CELLS 



TENSILE STRENGTH 



X. 



small quantities- 



\ 



Factors which diminish collagen production will result therefore in a lowered 

 tensile strength, e.g. Vitamin G deficiency (Taffel and Harvey, 1939; Wolfer et at., 

 1947) and protein deficiency (Harvey and Howes, 1930; Kobak et al., 1947; 

 Localio et al., 1948). 



IX. ALKALINE PHOSPHATASE 



The presence of alkaline phosphatase in healing wounds was first detected by 

 Fell and Danielli (1943), who observed two periods of maximum activity. The 

 first was associated with the formation of an eschar and could be related to the 

 concentration of polymorpho-nuclear leukocytes within the wound area. The 

 second period occurred somewhat later, concomitant with collagen formation. 



