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Lacaze (H.). LEtude des R6servoirs de Virus malarique indigenes en 

 Mac6doine. [The Study of native Reservoirs of the Malaria Virus 

 in Macedonia.]— 5mZL Soc. Path. Exoi., Paris, xi, no. 8, 9th October 

 1918, pp. 759-772. 

 The first prophylactic step towards reducing the native reservoirs 

 of the malaria virus in a given area must be the determination of the 

 intensity of infection in the villages of that region. The two methods 

 by which this can be done are by the search for the malarial paTasite 

 in the peripheral blood, and by determination of the endemic spleen 

 index. Ihe relative merits of these two methods are discussed, the 

 author being decidedly in favour of the second. The most reliable 

 index is obtained by examination of children between the ages of 18 

 months and 10 years ; prior to the minimum age, the child has been 

 less exposed to insect bites and the spleen has not had time to show 

 reaction to malarial infection ; after the maximum age, a certain 

 innnunity to, or tolerance of the virus makes it more difficult to 

 discover. A table shows the results of three examinations of all the 

 cases showing a positive reaction out of 184 children examined. The 

 results show that all new gamete carriers discovered at the second 

 examination were among those found to be suffering from enlarged 

 spleen during the first examination, thus confirming the malarial 

 nature of the affected spleens. A second table gives a resume of each 

 of the three examinations, showing the number of cases in which the 

 search for parasites and hypertrophy of the spleen were simultaneously 

 positive, and the number of cases in which one only of the tests proved 

 positive. Another table shows that the number of hypertrophied 

 spleens and the number of positive blood examinations undergo 

 seasonal variations, being higher in November than in June or January. 

 Examinations should therefore be made for preference during the 

 autumn. While the curve of the hypertrophied spleens and that of 

 the positive blood examinations run almost parallel, the former is 

 invariably higher than the latter. 



The results of these investigations indicate that even when the 

 parasites are not circulating in the peripheral blood, the spleen, in 

 the case of a native Macedonian child that has not been treated, ov has 

 been insufficiently or wrongly treated, remains the touchstone of 

 malarial infection and the evidence of the persistence of the pathogenic 

 protozoa. 



La Lucha contra el Paludismo. [The Campaign against Malaria.] — 

 Boletin Agric. Tecnica yEconomica, Madrid, x, no. 117, September 

 1918, pp. 785-792. 



The chief precautions that should be adopted for protection against 

 mosquitos are reviewed. The methods advocated include the usual 

 measures against the bite of the insect, several repellents for application 

 to the skin being recommended. Suggestions for the destruction of 

 the adults include fumigation with sulphuric anhydride, with a mixture 

 of camphor and phenic acid, with cresilol and creolin and with hydro- 

 cyanic acid and various other substances. Various culicide solutions 

 are recommended for spraying, and traps for catching the adults are 

 described. Measures against the earlier stages include suppression of 

 the breeding-places, oiling of pools, etc. Instructions for making 



