166 3 APPENDIX. 
poisons. In dogs the physiological action of lobeline is first manifest- 
ed by a paralysis of the voluntary movements and by a concomitant 
exaggeration of the reflexes. Later these effects are complicated by 
a paralysis of the motor nerves, analogous to that produced by curare, 
Through its paralyzing action on the cardiac branch of the pheumo- 
gastric, lobeline resembles in its action the nicotine group. In warm- 
blooded animals the influence of lobeline is found in a great exalta- 
tion of the respiratory activity, It produces an acceleration of the 
respiratory movement, which is more persistent when the pneumo- 
gastric nerves are intact than when they have been divided. Further, 
the amplitude of the respiratory movements is increased, and the 
power of the respiratory muscles appears to be also augmented, 
Under the influence of comparatively small doses of lobeline, the in- 
hibitory influence of the pneumogastric on the heart, as well as its 
action on the bronchial muscles, is suppressed. The respiratory 
muscles appear to receive especial stimulation from the respiratory 
centre when the latter is under the influence of lobeline; as a result, 
the work accomplished by the heart and respiratory muscles is great- 
ly augmented. In comparison with the other agents which stimulate 
the respiratory functions, lobeline y the advantage over hydro- 
cyanic acid in its freedom from depressing action, while it surpasses 
aspidospermine in energy. It therefore seems evident that the 
employment of lobeline as an anti-asthmatic is substantiated by experi- 
mental facts, though the author has not made any clinical experi- 
ments and offers no suggestions as to the proper form of employment 
of this alkaloid, (Archiv, fir Experimentelle Pathologie und Pharma- 
cologie, 26 Band, Heft 3 und 4.) 
H. Paschkis and A. Smita (Akademie d. Wissen., Wien, April 17; 
1890, through Chem. Zett., 1890, 594) use the following method for 
preparing lobeline: The herb of Lobelia inflata is extracted with 
water, acidified with acetic acid, the extract’ partly evaporated, made 
alkaline and extracted with ether. An extract was taken up with 
water and being acid was made alkaline and shaken with ether. 
The ether was evaporated and the alkaloid obtained as a thick oil 
of a yellow colour. For purifying, the alkaloid was dissolved in 
ether, shaken with water acidulated with hydrochloric acid, then 
made alkaline and taken up with ether. This was repeated three 
times, the ethereal solution then dried with potassium hydrate, and 
the ether distilled in an atmosphere of hydrogen, The free alkaloid 
