176 APPENDIX. 
The frog was placed under a large glass funnel and jumped about, 
a tap on the glass being sufficient to make it change its place. 
11-44 a.M.—Frog showed no inclination to move; when its back 
was touched with a glass rod it made feeble attempts to move its 
limbs ; some loss of power was evident, but there were no twitchings 
of the limbs or convulsive movements. 
11-46 a.M.—The frog did not move its limbs even when tapped 
on the back; the left leg appeared quite paralysed. 
11-50 A.m,—The limbs were quite lax, and might be placed in any 
position without the animal making any effort to move them. When 
placed on its back, it now and then made feeble attempts to move 
the right leg; then the movements stimulated slight twitchings: 
After this, and until its death at 12 noon, it lay motionless, the only 
sign of vitality being an occasional gasp’; limbs flaccid, no convulsions, 
As a control experiment, another frog, a little larger, was injected 
with the same amount of brucine. Two minutes after the injection it 
was perfectly motionless ; there was evidently loss of voluntary power 
over the limbs, en placed on its back and touched, it made no 
effort to move, but slight twitchings of the limbs were noticed, which 
€ more marked in about a couple of minutes. Touching the 
back, pinching the limbs, or even gentle tapping on the table, was 
now sufficient to produce rather feeble convulsive movements, but 
there was no spasm, except when thus regularly induced, The frog 
died about ten minutes after the injection. After death the limbs 
were not stiff but rather flaccid. 
Many of the reactions we have described as being afforded by 
the alkaloid we have provisionally termed pseudobrucine were iden- 
tical with those yielded by brucine; while, on the other hand, certain 
reactions were quite different. The history of the drug shows that 
itis employed as a domestic remedy in the treatment of a large 
number of affections, but there is no evidence to indicate that it is 
supposed to possess any toxic properties. When we are satisfied 
that we have obtained the alkaloid in a pure state, its ultimate 
composition, &c., will be determined. (C.J. H. Warden and Assistant 
Surgeon Chuni Lal Bose, Pharm. Journ., Aug., 1892.) 
Oleander as a diuretic and heart-tonic. 
F. v. Ocfele (Pharm. Pr., Oct. 24, 1891, pp- 2-5) draws attention 
to the action of this plant as a diuretic and heart-tonic in place of 
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