12 ROYAL SOCIETY OF CANADA 



mesenteric glands slightly enlarged. Kidneys: cloudy. No signs of tuber- 

 culosis. Cultures from heart-blood, sterile. 



Rabbit VI. 



Inoculated in leg. No signs of tuberculosis. 



Rabbit VII. 



Inoculated intraperitoneally. Given serum. Slight congestion of the 

 abdominal wall where the serum was given. All organs healthy. 



Rabbit VIII. 



Died in thirteen days. Inoculated in leg. No local signs in glands of 

 groin. Upper lobe of left lung much shrunken, full of large scattered 

 caseous masses. Caseous pleurisy with thickening. One or two minute 

 tubercles in apex of right lung. Other organs normal. Peribronchial glands 

 caseous. 



Rabbit IX. 



Inoculated in krg. Given serum. All organs healthy. No local signs 

 of the inoculation of the serum. 



Rabbit X. 



Died on twenty-first day. Incculated intraperitoneally. Given serum. 

 Subcutaneous tissues over site of inoculation slightly œdematous and red- 

 dened. A small caseous yellow spot on inner side of abdominal wall at 

 site of original inoculation. Condition of gastroenteritis present which 

 had apparently caused death. No other signs of tuberculosis elsewhere. 

 Cultures from the heart-blood and liver, sterile. 



It will be seen from the foregoing that of the guinea-pigs only one 

 (jSTo. 2), gave evidence of any dissemination of the tubercle bacilli to 

 a distance from the site of the original inoculation. It had not received 

 serum. In Nos. 1 and 4 the inguinal glands were affected; the bacilli 

 were recovered in No, 1 which had not received serum, not found in 

 No. 4 M'hich had. In No. 6, which had received serum, the infection 

 was strictly localized to the site of inoculation. In those inoculated in 

 the leg, viz., Nos. 3, 5, 7 and 8, all except one showed enlargement of 

 the inguinal glands. In only one that had not received serum were the 

 bacilli recovered (No. 3). One that had received serum did not develop 

 a local lesion (No. 8). 



In the case of the rabbits, only one developed gross tuberculosis 

 (No. 8), and this one had not received serum. This result was in gen- 

 eral what one would have expected as rabbits are much more refractory 

 to tuberculosis than are guinea-pigs. None of the culture tubes deve- 

 loped the specific bacillus, and when found in smears, they were in a 

 state of extreme fragmentation and degeneration, showing that the 

 infection was an extremely mild one. So far as I could see the inocu- 

 lations of serum had no effect whatever upon the temperature of the 

 animals receiving it, but the rabbits so treated lost weight rather rapid- 



