16 ROYAL SOCIETY OF CANADA 



rounded by a congested zone. Anterior mediastinal glands enlarged and 

 caseous. One or two retroperitoneal glands and a few inguinal ones enlarged 

 and possibly tuberculous. Sn^all pearly tubercles along vessels of mesentery 

 of small intestine. 



Great omentum, nodular and caseous. Other organs normal. Smears 

 from the spleen, liver, and anterior mediastinal gland gave B. Tuberculosis; 

 from peritoneal and left pleural fluid, negative. Cultures, sterile. 



Microscopic examination. Heart: Cloudy. Lung: Some alveolar catarrh, 

 numerous lymphocytes and leucocytes in the septa and alveolar walls, with 

 slight cellular exudation into the alveolar spaces. Spleen: Enlarged, contain- 

 ing large confluent caseous masses with nuclear fragmentation. Exudation 

 chiefly lymphocytes. No fibrosis. Liver: Numerous large tubercules in the 

 portal sheaths, consisting mainly of lymphocytes, with in places caseation. 

 Ischasmic necroses. Liver cells cloudy and fatty. Lymph-glands showed numer- 

 ous small masses of caseation without peripheral fibrosis. Abdominal wall: 

 Muscle fibres swollen and cloudy, with masses of lymphocytes and fairly 

 numerous epithelioid cells between the muscle bundles. No fibrosis. Supra- 

 renal and kidney, cloudy. 



Guinea-pig III. 



Inoculated intraperitoneally. Given one c.cm. of goat serum every 

 third day. Died in twenty days. Broken tooth and infected jaw. Caseous 

 focus in the abdominal wall at the site of inoculation, containing B. tuber- 

 culosis. Numerous small tubercles on lower portion of the peritoneum. 

 Smears from these gave B. Tuberculosis. Great omentum contained large 

 caseous nodules. Spleen and liver contained miliary tubercles. Films gave 

 the specific bacillus. Diaphragm on under surface was covered with miliary 

 tubercles. The anterior mediastinal glands enlarged and caseous, and a 

 few retroperitoneal glands in the lumbar region enlarged, reddened, and 

 showing beginning necrosis. Other organs free. Broth cultures from the 

 heart-blood remained sterile. 



Microscopic examination. Heart and kidneys: Cloudy. One minute patch 

 of haemorrhage with alveolar desquamation in the lung with but few leuco- 

 cytes. tSpleen: Follicles congested, pulp hyperplastic. Some large caseous 

 areas without fibrosis. Liver: Cloudy and congested, with some fatty degen- 

 eration. Small miliary tubercles present, in only one of which was there 

 beginning central caseation. A few epithelioid cells. No fibrosis. Great 

 omentum: Full of caseous masses; one giant-cell seen. Suprarenal: Congested; 

 a very small area of interstitial infiammation. Abdominal wall: Muscle fibres 

 dissociated by inflammatory products, cloudy and disintegrated. Caseating 

 tubercles with abundant lymphocytes fairly numerous epithelioid cells and 

 polymorphonuclear leuccocytes. No fibrosis. 



Guinea-pig V. 



Inoculated in leg. Given goat serum. On twenty-first day nodule with 

 infiltration of muscle at the site of inoculation. Killed on twenty-sixth day. 



A caseous mass the size of a filbert found at site of inoculation. Two 

 inguinal glands on left side enlarged and caseous and one on the light. 

 Retroperitoneal glands similar. Two or three mesenteric glands caseous. 

 Liver and spleen full of caseous masses. Minute tubercles in the great 

 omentum, not caseous. Lungs showed miliary tubercles, and one or two 

 of the anterior mediastinal glands enlarged, but not caseous. Kidneys, 



