[NicnoLLs] BLOOD SERA IN TUBERCULOUS INFECTION 17 



normal. Smear from the retroperitoneal glands gave B. Tuberculosis. Cul- 

 tures from the heart-blod and inguinal glands gave staphylococci, others 

 sterile. 



Microscopical examination. Heart and kidneys: Cloudy. Lung: fairly 

 numerous miliary tubercles, some just beginning to caseate. No fibrosis. 

 ISplccn: Very extensive caseation. Liver: Numerous and large tubercles 

 without caseation in the portal sheaths, consisting of abundant lympocytes 

 and fairly numerous epithelioid cells. Various glands showed caseous centres. 



Guinea-pig VI. 



Inoculated in leg. On twelfth day induration about site of dnoculation, 

 and one inguinal gland felt on the left side. On twenty-first day caseous 

 focus point in leg. Two Inguinal glands felt. On twenty-second day got 

 cheesy pus from abscess which contained fragmented bacilli of Tuberculosis. 

 Killed on the twenty-sixth day. 



At site of inoculation, a caseous abscess. A few inguinal glands on the 

 left side and several retroperitoneal glands enlarged and caseous. A few 

 small pearly tubercles on peritoneum in lower portion, but relatively few 

 on the diaphragm. Spleen enlarged, presenting a multitude of small pearly 

 tubercles. Liver contained numerous small caseous foci. Kidneys free. 

 A few mesenteric glands caseous. Lungs contain miliary tubercle!^. One 

 anterior mediastinal gland enlarged. Omentum contained a few tubercles. 

 Smears from the inguinal glands and spleen showed B. Tuberculosis. The 

 amount of tuberculosis present was not nearly so great as in pig V. 



Microscopical examination. Heart and kidneys: Cloudy. Lungs: Acute 

 congestion with infarction. Fairly numerous tubercles, one or two exten- 

 sively caseated, composed chiefly of lymphocytes. ISple(n: Fairly numerous 

 small tubercles with only slight caseation. Liver: Numerous large tubercles 

 in the portal sheaths without caseation, consisting of numerous lymphocytes 

 and fairly abundant epithelioid cells. 



Rabbit I. 



Inoculated intraperitoneally. Given serum. Killed on fiftieth day. One 

 caseous retroperitoneal gland was found just below right kidney, but smears 

 from this did not give tubercle bacilli. A small caseous tubercle in base 

 of right lung. Cultures, sterile. 



Microscopic examination. Lung: Infiltration with lymphocytes and large 

 mononuclear cells in septa about the great vessels. Other organs cloudy or 

 normal. 



Rabbit II. 



Inoculated intraperitoneally. Killed on fifty-first day. One or two small 

 caseous masses on surface of the large bowel, films from which gave the 

 B. Tuberculosis. A few caseous looking streaks along the lymphatics of 

 the mesentery. Two small retroperitoneal glands enlarged. Cultures, sterile. 



Microscopic examination. i\'odulcs from bowel: Caseous tubercles com- 

 posed chiefly of lymphocytes without giant-cells. Liver: Congested, numerous 

 polymorphonuclear, mononuclear cells and phagocytes containing pigment 

 and fragments of cells in the spaces between the liver cells. Other organs, 

 cloudy. 



Sec. IV., 1903. 2. 



