18 * EOYAL SOCIETY OF CANADA 



Rabbit III. 



Inoculated in leg. Given serum. On twelfth day one inguinal gland 

 felt. Killed on fifty-fourth day. No signs of tuberculosis at site of inocula- 

 tion. One or two glands found enlarged in the left leg, but no caseation 

 elsewhere. Positive evidence of presence of tuberculosis not found. Cul- 

 tures, sterile. Microscopical examination. Organs, cloudy. 



Rabbit XII. 



Inoculated in leg. On twenty-first day a small hard papule at site of 

 inoculation. Killed on forty-fourth day. Inflammatory infiltration with 

 caseation was found along the track of the inoculation, film from which 

 gave moderate numbers of tubercle bacilli. Three or four retroperitoneal 

 glands on the left side were enlarged and appeared to contain minute tuber- 

 cles, films, however, did not reveal the bacillus. A few minute pearly 

 tubercles were found in the mesentery along the course of the vessels. One 

 or two mesenteric glands slightly enlarged. 



Microscopical examination. Site of inoculation: Muscle fibres swollen, 

 cloudy, dissociated, and disintegrated. Considerable caseation with abundant 

 lymphocytes. Epilhedioid cells were rather more numerous than in the case 

 of the pigs. 



Rabbit IV. 



Inoculated intraperitoneally. Killed fifty-first day. Small caseous mass 

 at site of inoculation. Numerous minute pearly tubercles noted on posterior 

 part of peritoneum low down; also in lesser omentum and over stomach. Liver 

 contained scanty pin-point tubercles. Lungs contained fairly numerous 

 caseous tubercles the size of millet seeds. Smears from the lung and omen- 

 tum gave B. Tuberculosis. Culture from blood, sterile. 



Microscopical examination. Lung: Several miliary tubercles composed 

 chiefly of epithelioid cells with rare lymphocytes. No caseation nor fibrosis. 

 Spleen: hyperplasia of follicles. Liver: Contained miliary tubercles of small 

 size, composed chiefly of epithelioid cells with a few lymphocytes at the 

 periphery. 



Rabbit XI. 



Inoculated intraperitoneally. Given serum. Died on forty-first day. 

 Much emaciated. The base of the left lung was rather reddened and con- 

 tained a large miliary tubercle. A smear from this gave the specific bacillus. 

 A few whitish miliary foci found elsewhere in the lung. 



Microscopical examination. Lung: Showed several rather diffuse areas of 

 inflammatory infiltration composed of lymphocytes and epithelioid cells. No 

 caseation nor fibrosis. Spleen: Slight hyperplasia, contained numerous phago- 

 cytes with blood pigment. Other organsi negative. This rabbit apparently 

 died from the effect of tlie inoculations which had brought about some haemo- 

 lysis. 



Rabbit VII. 



Inoculated in leg. On twenty-first day a very small papule felt at site of 

 inoculation. Killed on fifty-fifth day. Abscess with puriform matter and 

 numerous tubercles at site of inoculation, containing numerous tubercle 

 bacilli. One or two mesenteric glands enlarged. Culture from blood, sterile. 



Microscopic examination. Site of inoculation: Caseous tuberculosis with 



