[nicholls] blood sera IN TUBERCULOUS INFECTION 2S 



able swelling and injection of the iris with exudation and marked con- 

 iunctivitis. One c. cm. of the fortified serum was then given every third 

 day. Following upon this the acute iritis and conjunctivitis subsided, 

 and during the next three weeks that the animal was kept under obser- 

 vation while the disease undoubtedly progressed and subsidiary tuber- 

 cles formed, there were no evidences of acute trouble, and the progres- 

 sion of the tuberclosis was somewhat slow and indolent. 



With regard to temperatures, the average of all the pigs was 102.4° 

 b.efore inoculation. After inoculation the average of those receiving 

 serum was 102.3°; of those not receiving it, 102°. 



CONCLUSIOXS. 



From these various results it would look as if the injection of the 

 antitoxic serum exercised a certain amount of restraining influence 

 upon the extent and development of the disease although it is equally 

 clear that it was not powerful enough to neutralize the infection or 

 prevent its extension. Under ordinary circumstances I would hesitate 

 to draw these conclusions from such a small series of animals were it 

 not for the fact that my results are in perfect accord with work pre- 

 viously done on somewhat analogous lines. As a result of this study, 

 taken in the light also of the results of other observers, I am led to the 

 following conclusions: — 



(1) That normal goat serum when injected into guinea-pigs and 

 rabbits is practically innocuous, only rarely producing any hsemolysis. 



(2) When injected with care it appears to stimulate nutrition 

 rather than otherwise. 



(3) Normal goat serum possesses a slight amount of antitoxic 

 power against tuberculosis in rabbits. 



(4) This natural antitoxic power may be considerably increased by 

 injecting the goat with gradually increasing doses of Koch's New Tuber- 

 culin (Bacillenemulsion) until immune to its effects. 



(5) Antitoxic serum produced in this way has some power in 

 retarding tuberculous processes, although it is not strong enough to 

 cure them. 



(6) The injections of the antitoxic serum have no effect on tem- 

 perature. 



I believe, therefore, that it is possible to prepare an antitoxic 

 seruml for use in tuberculosis that will in a notable degree retard the 

 disease in certain of the lower animals. Whether we shall be able to 

 increase its power so as to bring about cure is another matter. In the 

 case of the protective serum I have produced I did not expect even such 



