The Kauffmann-White Schema (1955) — Concluded 



In accordance with the opinion of the majority of the Subcommittee members, the sym- 

 bols used to express the O antigens of Salmonella have been changed from Roman to Ara- 

 bic numerals. 



It was shown by Edwards and Moran (Proc. Soc. Exp. Biol, and Med., 66, 1947, 230) that 

 Salmonella sp. (Type Senftenberg) and Salmonella sp. (Type Simsbury) each could be 

 transformed into the other. Bruner and Edwards (Jour. Bact., 55, 1948, 449) found that in 

 certain instances antigen 3, 10 could be changed to antigen 3, 15 and again reversed to 3, 

 10. Bruner (Jour. Bact., 57, 1949, 387) obtained typical cultures of Salmonella sp. (Type 

 (Oranienburg) from certain strains of Salmonella sp. (Type Montevideo). These antigenic 

 changes, all of which were produced by induced variation, are of great interest and un- 

 doubtedly throw light on phylogeny and evolution within the group. Further, it is highly 

 probable that such changes occur in nature. However, the epidemiological significance of 

 the various Salmonella types is well established, and observations such as those cited above 

 in no way detract from the value of antigenic typing in the study of the epidemiology of 

 Salmonella infections. For this reason the types are listed in the schema as they are found 

 in nature. 



No antigenic relationship exists between the H antigens Zi , z-i , z^ , etc. The symbol 

 z affixed by the numeral was chosen to denote these antigens, as no other letters of the al- 

 phabet were available. 



383 



