[CAMERON] VERTEBRATE STRIATED MUSCLE 83 



most intense reaction ta the effects of this staining agent, and stand 

 out in striking contrast to the more achromatic portions of developing 

 muscle tissue. The result is a very vivid sharply defined micro- 

 photograph. Another obvious advantage of this stain is, that it is 

 not necessary to have recourse to special orthochromatic plates in 

 preparing thé microphotographs. 



IV. The Myo-Syncytium. 



Our knowledge of the histogenesis of striated muscle is still in a 

 very imperfect state, if one may judge from the description given in a 

 standard work like Keibel and Mall's Human Embryology, which is 

 founded mainly on the researches of one investigator, Godlewski, 

 many of whose results will be found referred to in detail throughout 

 this paper. The work of this investigator forms the most modern 

 contribution to our knowledge of the subject, though it was published 

 fifteen years ago, and it is in many ways a most valuable one. Godlew- 

 ski' and Maurer- were amongst the first to show that the myotome 

 is structurally a syncytium. Extensive researches on the development 

 of striated muscle were made by Balfour^ Mayer*, Barfurth^ and 

 Paneth^ during the eighties. These were continued during the 

 nineties by Kazzander", Kollmann^ Kroesig^ MacCallum'^ Meek^S 

 Morpurgo,i2 Reuter^^ and Schaffer,!" who contributed largely to our 

 knowledge of this subject. The work of these investigators will be 

 found referred to in various parts of this paper. More recently, 

 Bardeen^s and Lewis^" have made a long series of valuable researches 

 on both the histogenesis and the morphology of striated muscle. It is 

 likewise important to mention that cytological investigations on the 

 behaviour of the nuclei of the striated muscle fibres of Necturus were 



'Op. cit. 



^Series of papers in Morpol. Jahrbuch, 1892-1898. 



«Comparât. Embryol., Vol. II, 1885. 



^Op. cit. 



^Op. cit. 



sSitz. der Wiener Akadamie, Bd., 92, 1885. 



^Anat. Anzeiger, Bd. VI, 1891. 



«Archiv fur Anat. und Phys., 1891. 



«Virchow's Archiv., Bd. 128, 1892. 



lojohns Hopkins Hosp. Bulletin, 1898. 



"Jour. Anat. and Phys., Vol. 33, 1899. 



i^Anat. Anzeiger, Bd. 15 and 16, 1898-1899. 



i^Anat. Hefte., Bd. 7 and 9, 1896 and 1897. 



i^Sitz. der Wiener Akadamie, Bd., 102, 1893. 



i^Op. cit. 



'5 and l'Amer. Jour, of Anat., Vol. I, 1901. 



